Phosphorylation and activation of eIF4B by activated S6K1

Stable Identifier
R-HSA-165777
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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eIF4B is a physiologically relevant target of S6K1. Once phosphorylated and activated by S6K1, eIF4B specifically stimulates the ATPase and RNA helicase activities of eIF4A.

Literature References
PubMed ID Title Journal Year
15314020 Upstream and downstream of mTOR

Hay, N, Sonenberg, N

Genes Dev 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
kinase activity of p-S371,T389-RPS6KB1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created