Phosphorylation and inactivation of eEF2K by activated S6K1

Stable Identifier
R-HSA-165758
Type
Reaction
Species
Homo sapiens
Compartment
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Phosphorylation of eEF2 kinase by S6K1-P results in decreased activity of this kinase. eEF2 kinase normally phosphorylates and deactivates eEF2, preventing its binding to the ribosome.

Literature References
PubMed ID Title Journal Year
15809305 Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR

Ali, SM, Sabatini, DM

J Biol Chem 2005
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-S371,T389-RPS6KB1 [cytosol]

Orthologous Events
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