Phosphorylation and inactivation of eEF2K by activated S6K1

Stable Identifier
R-HSA-165758
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation and inactivation of eEF2K by activated S6K1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylation of eEF2 kinase by S6K1-P results in decreased activity of this kinase. eEF2 kinase normally phosphorylates and deactivates eEF2, preventing its binding to the ribosome.

Literature References
PubMed ID Title Journal Year
15809305 Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR

Ali, SM, Sabatini, DM

J Biol Chem 2005
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S371,T389-RPS6KB1 [cytosol]
Physical Entity
p-S371,T389-RPS6KB1 [cytosol]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
Phosphorylation and inactivation of eEF2K by activated S6K1 (Bos taurus)
Phosphorylation and inactivation of eEF2K by activated S6K1 (Caenorhabditis elegans)
Phosphorylation and inactivation of eEF2K by activated S6K1 (Canis familiaris)
Phosphorylation and inactivation of eEF2K by activated S6K1 (Danio rerio)
Phosphorylation and inactivation of eEF2K by activated S6K1 (Dictyostelium discoideum)
Phosphorylation and inactivation of eEF2K by activated S6K1 (Gallus gallus)
Phosphorylation and inactivation of eEF2K by activated S6K1 (Mus musculus)
Phosphorylation and inactivation of eEF2K by activated S6K1 (Rattus norvegicus)
Phosphorylation and inactivation of eEF2K by activated S6K1 (Sus scrofa)
Phosphorylation and inactivation of eEF2K by activated S6K1 (Xenopus tropicalis)
Authored
Jupe, S  (2015-01-23)
Reviewed
Zwartkruis, FJ  (2015-05-14)
Created
de Bono, B  (2005-08-09)