Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-S366-EEF2K [cytosol]
Stable Identifier
R-HSA-165755
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eEF2K-P
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
mTORC1-mediated signalling (Homo sapiens)
Phosphorylation and inactivation of eEF2K by activated S6K1 (Homo sapiens)
p-S366-EEF2K [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00418 EEF2K
Gene Names
EEF2K
Chain
initiator methionine:, chain:2-725
Reference Genes
BioGPS Gene:29904 EEF2K
COSMIC (genes):EEF2K EEF2K
CTD Gene:29904 EEF2K
dbSNP Gene:29904 EEF2K
ENSEMBL:ENSG00000103319 EEF2K
HGNC:24615 EEF2K
KEGG:hsa:29904 EEF2K
Monarch:29904 EEF2K
NCBI Gene:29904 EEF2K
OMIM:606968 EEF2K
UCSC:O00418 EEF2K
Reference Transcript
RefSeq:NM_013302.3 EEF2K
RefSeq:XM_005276497.3 EEF2K
RefSeq:XM_017023193.1 EEF2K
Other Identifiers
11728792_x_at
11728793_s_at
16816813
225545_PM_at
225545_at
225546_PM_at
225546_at
2512222
29904
3652425
3652426
3652427
3652428
3652429
3652433
3652434
3652435
3652436
3652437
3652438
3652440
3652442
3652443
3652444
3652445
3652446
3652448
3652449
3652451
3652453
3652454
3652456
3652457
3652458
3652459
3652460
3652461
3652462
3652463
3652464
3652465
3652466
3652478
3652484
44080_at
50264_at
7993946
A_14_P124147
A_23_P140792
A_24_P125067
A_33_P3342410
GE80786
GE85715
GO:0002931
GO:0003824
GO:0004672
GO:0004674
GO:0004686
GO:0005509
GO:0005515
GO:0005516
GO:0005524
GO:0005737
GO:0005829
GO:0006414
GO:0006468
GO:0007010
GO:0008135
GO:0014069
GO:0016740
GO:0031037
GO:0031952
GO:0032869
GO:0043066
GO:0043197
GO:0043226
GO:0045182
GO:0045807
GO:0046777
GO:0051965
GO:0061003
GO:0071277
GO:0071320
GO:0071454
GO:0098978
GO:0140096
GO:0140245
GO:1990416
GO:1990637
HMNXSV003024551
Hs.259855.0.S2_3p_at
Hs.259855.0.S3_3p_at
ILMN_1789171
ILMN_1816367
PH_hs_0032368
TC16000243.hg
Participates
as an output of
Phosphorylation and inactivation of eEF2K by activated S6K1 (Homo sapiens)
Other forms of this molecule
EEF2K [cytosol]
Inferred To
phospho-EEF2K [cytosol]
(Bos taurus)
phospho-EEF2K [cytosol]
(Canis familiaris)
phospho-EEF2K [cytosol]
(Sus scrofa)
phospho-eef2k [cytosol]
(Xenopus tropicalis)
phospho-mhkD [cytosol]
(Dictyostelium discoideum)
phospho-p-S366-EEF2K [cytosol]
(Caenorhabditis elegans)
phospho-p-S366-EEF2K [cytosol]
(Gallus gallus)
phospho-p-S366-EEF2K [cytosol]
(Mus musculus)
phospho-p-S366-EEF2K [cytosol]
(Rattus norvegicus)
Modified Residues
Name
O-phospho-L-serine at 366
Coordinate
366
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
Guide to Pharmacology - Targets
2014
ENSEMBL
ENST00000263026
,
ENSP00000263026
,
ENSG00000103319
OpenTargets
ENSG00000103319
ZINC - Substances
EF2K_HUMAN
ZINC target
O00418
PRO
O00418
GlyGen
O00418
PDB
5J8H
,
5KS5
,
7SHQ
,
8FO6
,
8GM4
,
6NX4
,
8FNY
,
8GM5
GeneCards
EEF2K
HPA
ENSG00000103319-EEF2K
Pharos - Targets
O00418
ZINC - Predictions - Purchasable
EF2K_HUMAN
HMDB Protein
HMDBP07663
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.643
3
UniProt:Q9Y2J2 EPB41L3
1
EPB41L3 [cytosol]
(R-HSA-6797563)
0.527
2
UniProt:P11171 EPB41
1
EPB41 [cytosol]
(R-HSA-420411)
0.527
2
UniProt:Q9H4G0 EPB41L1
2
EPB41L1 [plasma membrane]
(R-HSA-416333)
EPB41L1 [cytosol]
(R-HSA-392241)
0.527
2
UniProt:O75344 FKBP6
2
FKBP6 [nucleoplasm]
(R-HSA-912512)
FKBP6 [cytosol]
(R-HSA-5601923)
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text