Thiosulfate can transfer its sulfur atom to glutathione

Stable Identifier
R-HSA-1655879
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
mitochondrial matrix
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Thiosulfate can transfer its sulfur atom to glutathione
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Thiosulfate is able to transfer its sulfur atom to glutathione, a reaction investigated in yeast (Chauncey & Westley 1983). Recombinant human thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1 (TSTD1 aka KAT1) (and its yeast equivalent RDL1) catalyse a predicted thiosulfate-dependent conversion of glutathione (GSH) to glutathione disulfide (GSSG) (Melideo et al. 2014).

Literature References
PubMed ID Title Journal Year
6361026 The catalytic mechanism of yeast thiosulfate reductase

Chauncey, TR, Westley, J

J Biol Chem 1983
24981631 Biosynthesis of a central intermediate in hydrogen sulfide metabolism by a novel human sulfurtransferase and its yeast ortholog

Melideo, SL, Jackson, MR, Jorns, MS

Biochemistry 2014
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
thiosulfate-thiol sulfurtransferase activity of TSTD1 [cytosol]
Physical Entity
TSTD1 [cytosol]
Activity
thiosulfate-thiol sulfurtransferase activity (0050337)
Orthologous Events
Thiosulfate can transfer its sulfur atom to glutathione (Bos taurus)
Thiosulfate can transfer its sulfur atom to glutathione (Canis familiaris)
Thiosulfate can transfer its sulfur atom to glutathione (Mus musculus)
Thiosulfate can transfer its sulfur atom to glutathione (Rattus norvegicus)
Thiosulfate can transfer its sulfur atom to glutathione (Sus scrofa)
Authored
Jassal, B  (2011-10-13)
Reviewed
D'Eustachio, P  (2011-10-13)
Created
Jassal, B  (2011-10-13)
Cite Us!