Thiosulfate can transfer its sulfur atom to glutathione

Stable Identifier
R-HSA-1655879
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
mitochondrial matrix
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Thiosulfate can transfer its sulfur atom to glutathione
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Thiosulfate is able to transfer its sulfur atom to glutathione, a reaction investigated in yeast (Chauncey & Westley 1983). Recombinant human thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1 (TSTD1 aka KAT1) (and its yeast equivalent RDL1) catalyse a predicted thiosulfate-dependent conversion of glutathione (GSH) to glutathione disulfide (GSSG) (Melideo et al. 2014).

Literature References
PubMed ID Title Journal Year
24981631 Biosynthesis of a central intermediate in hydrogen sulfide metabolism by a novel human sulfurtransferase and its yeast ortholog

Melideo, SL, Jorns, MS, Jackson, MR

Biochemistry 2014
6361026 The catalytic mechanism of yeast thiosulfate reductase

Chauncey, TR, Westley, J

J Biol Chem 1983
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Catalyst Activity

thiosulfate-thiol sulfurtransferase activity of TSTD1 [cytosol]

Physical Entity
TSTD1 [cytosol] (Homo sapiens)
Activity
thiosulfate-thiol sulfurtransferase activity (GO:0050337)
Orthologous Events
Thiosulfate can transfer its sulfur atom to glutathione (Bos taurus)
Thiosulfate can transfer its sulfur atom to glutathione (Canis familiaris)
Thiosulfate can transfer its sulfur atom to glutathione (Mus musculus)
Thiosulfate can transfer its sulfur atom to glutathione (Rattus norvegicus)
Thiosulfate can transfer its sulfur atom to glutathione (Sus scrofa)
Authored
Jassal, B  (2011-10-13)
Reviewed
D'Eustachio, P  (2011-10-13)
Created
Jassal, B  (2011-10-13)
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