Reactome | Thiosulfate can transfer its sulfur atom to glutathione

Thiosulfate can transfer its sulfur atom to glutathione

Stable Identifier

R-HSA-1655879

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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Thiosulfate can transfer its sulfur atom to glutathione

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Thiosulfate is able to transfer its sulfur atom to glutathione, a reaction investigated in yeast (Chauncey & Westley 1983). Recombinant human thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1 (TSTD1 aka KAT1) (and its yeast equivalent RDL1) catalyse a predicted thiosulfate-dependent conversion of glutathione (GSH) to glutathione disulfide (GSSG) (Melideo et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24981631	Biosynthesis of a central intermediate in hydrogen sulfide metabolism by a novel human sulfurtransferase and its yeast ortholog Melideo, SL, Jorns, MS, Jackson, MR	Biochemistry	2014
6361026	The catalytic mechanism of yeast thiosulfate reductase Chauncey, TR, Westley, J	J Biol Chem	1983