SREBP1A,1C,2:SCAP binds CopII Coat Complex

Stable Identifier
R-HSA-1655825
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Synonyms
SREBF1A,1C,2:SCAP binds CopII Coat Complex
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SREBPs (SREBP1A, SREBP1C, SREBP2, also known as SREBFs) are transmembrane proteins that bind SCAP in the endoplasmic reticulum membrane. In the presence of cholesterol or oxysterols SCAP:SREBP1A/1C/2 binds INSIG and is retained in the endoplasmic reticulum. At cholesterol concentrations below 5 mol% SCAP changes conformation, SCAP:SREBP1A/1C/2 loses interaction with INSIG, binds the CopII coat complex, and is translocated to the Golgi.

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