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SREBP1A,1C,2:SCAP binds CopII Coat Complex
Stable Identifier
R-HSA-1655825
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
SREBF1A,1C,2:SCAP binds CopII Coat Complex
ReviewStatus
5/5
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Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
SREBP1A,1C,2:SCAP binds CopII Coat Complex (Homo sapiens)
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SREBPs (SREBP1A, SREBP1C, SREBP2, also known as SREBFs) are transmembrane proteins that bind SCAP in the endoplasmic reticulum membrane. In the presence of cholesterol or oxysterols SCAP:SREBP1A/1C/2 binds INSIG and is retained in the endoplasmic reticulum. At cholesterol concentrations below 5 mol% SCAP changes conformation, SCAP:SREBP1A/1C/2 loses interaction with INSIG, binds the CopII coat complex, and is translocated to the Golgi.
Participants
Input
SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane]
(Homo sapiens)
SREBP1A,1C,2:SCAP [endoplasmic reticulum membrane]
(Homo sapiens)
Output
SREBP1A,1C,2:SCAP:Cop II Coat [endoplasmic reticulum membrane]
(Homo sapiens)
Participates
as an event of
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Inferred From
SREBP2:SCAP Binds CopII Coat Complex (Cricetulus griseus)
Authored
May, B (2011-09-28)
Reviewed
Liang, G (2012-08-26)
Created
May, B (2011-10-13)
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