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SREBF1-3 [nucleoplasm]
Stable Identifier
R-HSA-1655716
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SREBF1C(1-466), SREBP1C(1-466), SREBF1C cleaved by S2P, Sterol regulatory element-binding protein 1C, SRBP1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1) (Homo sapiens)
SREBP1A,1C:ACACA gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C dimer [nucleoplasm] (Homo sapiens)
SREBF1A,C [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
Expression of Acetyl CoA Carboxylase 2 (ACACB, ACC2) (Homo sapiens)
SREBP1A,1C:ACACB gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C dimer [nucleoplasm] (Homo sapiens)
SREBF1A,C [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD) (Homo sapiens)
SREBP1A,1C:SCD gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C dimer [nucleoplasm] (Homo sapiens)
SREBF1A,C [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
Expression of ELOVL6 (Homo sapiens)
SREBP1A,1C,2:ELOVL6 gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
Expression of Farnesyl Diphosphate Synthase (FDPS) (Homo sapiens)
SREBP1A,1C,2:NF-Y:FDPS gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
Expression of Fatty Acid Synthase (FASN) (Homo sapiens)
SREBP1A,1C:NF-Y:SP1:FASN gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C dimer [nucleoplasm] (Homo sapiens)
SREBF1A,C [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT) (Homo sapiens)
SREBP1A,1C:NF-Y:GPAM gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C dimer [nucleoplasm] (Homo sapiens)
SREBF1A,C [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
SREBP1A,1C,2:NF-Y:HMGCS1 gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
Expression of TM7SF2 (Homo sapiens)
SREBP1A,1C,2:NF-Y:TM7SF2 gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C binds the ACACB promoter (Homo sapiens)
SREBP1A,1C dimer [nucleoplasm] (Homo sapiens)
SREBF1A,C [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C:ACACB gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C dimer [nucleoplasm] (Homo sapiens)
SREBF1A,C [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C binds the FASN promoter (Homo sapiens)
SREBP1A,1C dimer [nucleoplasm] (Homo sapiens)
SREBF1A,C [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C:NF-Y:SP1:FASN gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C dimer [nucleoplasm] (Homo sapiens)
SREBF1A,C [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C binds the GPAM promoter (Homo sapiens)
SREBP1A,1C dimer [nucleoplasm] (Homo sapiens)
SREBF1A,C [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C:NF-Y:GPAM gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C dimer [nucleoplasm] (Homo sapiens)
SREBF1A,C [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C binds the SCD gene (Homo sapiens)
SREBP1A,1C dimer [nucleoplasm] (Homo sapiens)
SREBF1A,C [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C:SCD gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C dimer [nucleoplasm] (Homo sapiens)
SREBF1A,C [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 binds the ACACA promoter (Homo sapiens)
SREBP1A,1C dimer [nucleoplasm] (Homo sapiens)
SREBF1A,C [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C:ACACA gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C dimer [nucleoplasm] (Homo sapiens)
SREBF1A,C [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 binds the ELOVL6 promoter (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:ELOVL6 gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 binds the FDFT1 promoter (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 binds the FDPS promoter (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:NF-Y:FDPS gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 binds the HMGCS1 promoter (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:NF-Y:HMGCS1 gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 binds the TM7SF2 promoter (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:NF-Y:TM7SF2 gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 translocates to the nucleus (Homo sapiens)
SREBP1A,1C,2:Importin beta-1 [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:Importin beta-1 dissociates (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2:Importin beta-1 [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
SREBP1A,1C,2:NF-Y:HMGCS1 gene [nucleoplasm] (Homo sapiens)
SREBP1A,1C,2 dimer [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
SREBF1-3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P36956-3 SREBF1
Gene Names
SREBF1, BHLHD1, SREBP1
Participates
as a member of
SREBF1A,C [nucleoplasm] (Homo sapiens)
SREBF1A,1C,2 cleaved by S2P [nucleoplasm] (Homo sapiens)
Other forms of this molecule
SREBF1-3 [endoplasmic reticulum membrane]
SREBF1-3 [Golgi membrane]
SREBF1-3 [Golgi membrane]
SREBF1-3 [cytosol]
Inferred To
srebf1 [nucleoplasm]
(Danio rerio)
srebf1 [nucleoplasm]
(Xenopus tropicalis)
SREBP [nucleoplasm]
(Drosophila melanogaster)
sbp-1 [nucleoplasm]
(Caenorhabditis elegans)
SREBF1 [nucleoplasm]
(Bos taurus)
SREBF1 [nucleoplasm]
(Canis familiaris)
SREBF1 [nucleoplasm]
(Sus scrofa)
Srebf1 [nucleoplasm]
(Mus musculus)
Srebf1 [nucleoplasm]
(Rattus norvegicus)
SREBF1-3 [nucleoplasm]
(Gallus gallus)
Cross References
ENSEMBL
ENSP00000379106
,
ENST00000261646
,
ENSP00000261646
,
ENSG00000072310
,
ENST00000395757
,
ENST00000355815
,
ENSP00000348069
OpenTargets
ENSG00000072310
GeneCards
SREBF1
HPA
ENSG00000072310-SREBF1
PRO
P36956
Pharos - Targets
P36956
GlyGen
P36956
PDB
1AM9
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54253 ATX1
0.666
5
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
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