GTP loading by Rheb

Stable Identifier
R-HSA-165195
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Rheb is a GTP binding protein that exhibits GTPase activity. GDP is exchanged for GTP in the [Rheb:GDP] complex to form [Rheb:GTP], which binds and activates the mTORC1 complex. The GDP-bound form of Rheb also binds mTORC1 but does not lead to activation. This exchange may be catalysed by an as yet unidentified guanine exchange factor (GEF); the intrinsic exchange activity of Rheb may be sufficient in the absence of a GEF.

Literature References
PubMed ID Title Journal Year
15755954 Signaling by target of rapamycin proteins in cell growth control

Inoki, K, Ouyang, H, Li, Y, Guan, KL

Microbiol Mol Biol Rev 2005
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