GTP loading by Rheb

Stable Identifier
R-HSA-165195
Type
Reaction [transition]
Species
Homo sapiens
Compartment
lysosomal membrane, cytosol
ReviewStatus
5/5
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GTP loading by Rheb
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Rheb is a GTP binding protein that exhibits GTPase activity. GDP is exchanged for GTP in the [Rheb:GDP] complex to form [Rheb:GTP], which binds and activates the mTORC1 complex. The GDP-bound form of Rheb also binds mTORC1 but does not lead to activation. This exchange may be catalysed by an as yet unidentified guanine exchange factor (GEF); the intrinsic exchange activity of Rheb may be sufficient in the absence of a GEF.
Literature References
PubMed ID Title Journal Year
15755954 Signaling by target of rapamycin proteins in cell growth control

Inoki, K, Guan, KL, Ouyang, H, Li, Y

Microbiol Mol Biol Rev 2005
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Orthologous Events
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Authored
Jupe, S  (2015-01-23)
Reviewed
Zwartkruis, FJ  (2015-05-14)
Created
de Bono, B  (2005-08-02)
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