Phosphorylation of TSC2 by PKB

Stable Identifier
R-HSA-165162
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Phosphorylation of TSC2 by PKB
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PKB phosphorylates TSC2 decreasing its activity and disrupting TSC1:TSC2 heterodimer formation (Hay & Sonenberg 2004) which induces ubiquination of the free TSC2 (Inoki et al. 2002).

Literature References
PubMed ID Title Journal Year
15314020 Upstream and downstream of mTOR

Hay, N, Sonenberg, N

Genes Dev 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T309,S474-AKT2:PIP3 [plasma membrane]
Physical Entity
p-T309,S474-AKT2:PIP3 [plasma membrane]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
Phosphorylation of TSC2 by PKB (Bos taurus)
Phosphorylation of TSC2 by PKB (Canis familiaris)
Phosphorylation of TSC2 by PKB (Danio rerio)
Phosphorylation of TSC2 by PKB (Dictyostelium discoideum)
Phosphorylation of TSC2 by PKB (Drosophila melanogaster)
Phosphorylation of TSC2 by PKB (Mus musculus)
Phosphorylation of TSC2 by PKB (Rattus norvegicus)
Phosphorylation of TSC2 by PKB (Schizosaccharomyces pombe)
Phosphorylation of TSC2 by PKB (Sus scrofa)
Phosphorylation of TSC2 by PKB (Xenopus tropicalis)
Authored
Jupe, S  (2015-01-23)
Reviewed
Zwartkruis, FJ  (2015-05-14)
Created
de Bono, B  (2005-08-01)