PKB phosphorylates TSC2 decreasing its activity and disrupting TSC1:TSC2 heterodimer formation (Hay & Sonenberg 2004) which induces ubiquination of the free TSC2 (Inoki et al. 2002).
Hay, N, Sonenberg, N
protein serine/threonine kinase activity of p-T309,S474-AKT2:PIP3 [plasma membrane]
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