Phosphorylation of TSC2 by PKB

Stable Identifier
R-HSA-165162
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PKB phosphorylates TSC2 decreasing its activity and disrupting TSC1:TSC2 heterodimer formation (Hay & Sonenberg 2004) which induces ubiquination of the free TSC2 (Inoki et al. 2002).

Literature References
PubMed ID Title Journal Year
15314020 Upstream and downstream of mTOR

Hay, N, Sonenberg, N

Genes Dev 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T309,S474-AKT2:PIP3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created