PDE3B signalling

Stable Identifier
R-HSA-165160
Type
Pathway
Species
Homo sapiens
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AKT (PKB) is recruited to the plasma membrane by binding phosphatidylinositol (3,4,5)-trisphosphate (PIP3). AKT is then activated by phosphorylation. Activated AKT in turn phosphorylates Phosphodiesterase 3B (PDE3B) which hydrolyzes 3',5'-cyclic AMP (cAMP) (reviewed in Manning and Toker 2017).

Literature References
PubMed ID Title Journal Year
28431241 AKT/PKB Signaling: Navigating the Network

Manning, BD, Toker, A

Cell 2017
Participants
Participant Of
Orthologous Events
Created