AKT (PKB) is recruited to the plasma membrane by binding phosphatidylinositol (3,4,5)-trisphosphate (PIP3). AKT is then activated by phosphorylation. Activated AKT in turn phosphorylates Phosphodiesterase 3B (PDE3B) which hydrolyzes 3',5'-cyclic AMP (cAMP) (reviewed in Manning and Toker 2017).
