Nef and signal transduction

Stable Identifier
R-HSA-164944
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
ReviewStatus
5/5
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Nef and signal transduction
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Nef interferes with cellular signal transduction pathways in a number of ways. Nef is associated with lipid rafts through its amino-terminal myristoylation and a proline-rich SH3-binding domain. These cholesterol-rich membrane microdomains appear to concentrate potent signaling mediators. Nef was found to complex with and activate serine/threonine protein kinase PAK-2, which may contribute to activation of infected cells. In vitro, HIV-infected T cells produce enhanced levels of interleukin-2 during activation. When expressed in macrophages, Nef intersects the CD40L signaling pathway inducing secretion of chemokines and other factors that attract resting T cells and promote their infection by HIV.
Literature References
PubMed ID Title Journal Year
10618429 The Nef protein of HIV-1 associates with rafts and primes T cells for activation

Trono, D, Wang, JK, Verdin, E, Kiyokawa, E

Proc Natl Acad Sci U S A 2000
12853962 HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection

Ulich, C, Zhou, J, Swingler, S, Brichacek, B, Stevenson, M, Jacque, JM

Nature 2003
8570619 Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes

Raabe, T, Nottet, HS, Nuovo, G, Flanagan, CR, Sherry, B, Cerami, A, Bukrinsky, M, Schmidtmayerova, H, Gendelman, HE, Dubrovsky, L

Proc Natl Acad Sci U S A 1996
Participants
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Event Information
Go Biological Process
mitigation of host antiviral defense response (0019049)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Gillespie, ME  (2007-07-25)
Reviewed
Skowronski, J  (2007-08-07)
Created
Gillespie, ME  (2005-07-23)
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