Reactome | ATP5MC1 [mitochondrial inner membrane]

ATP5MC1 [mitochondrial inner membrane]

Stable Identifier

R-HSA-164535

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

ATP5G1, ATP synthase lipid-binding protein, ATP synthase proteolipid P1, ATPase protein 9, ATPase subunit c, ATP synthase F(0) complex subunit C1

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Aerobic respiration and respiratory electron transport (Homo sapiens)
  - Formation of ATP by chemiosmotic coupling (Homo sapiens)
    - ADP and Pi bind to ATPase (Homo sapiens)
      - ATPase:ADP:Pi [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP synthase subunit c [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5MC1 [mitochondrial inner membrane] (Homo sapiens)
      - F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP synthase subunit c [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5MC1 [mitochondrial inner membrane] (Homo sapiens)
    - ATPase synthesizes ATP (Homo sapiens)
      - ATPase:ADP:Pi [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP synthase subunit c [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5MC1 [mitochondrial inner membrane] (Homo sapiens)
      - ATPase:ATP [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP synthase subunit c [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5MC1 [mitochondrial inner membrane] (Homo sapiens)
      - F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP synthase subunit c [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5MC1 [mitochondrial inner membrane] (Homo sapiens)
    - Enzyme-bound ATP is released (Homo sapiens)
      - ATPase:ATP [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP synthase subunit c [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5MC1 [mitochondrial inner membrane] (Homo sapiens)
      - F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP synthase subunit c [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5MC1 [mitochondrial inner membrane] (Homo sapiens)

Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Cristae formation (Homo sapiens)
    - F1Fo ATP synthase dimerizes (Homo sapiens)
      - F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP synthase subunit c [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5MC1 [mitochondrial inner membrane] (Homo sapiens)
      - F1Fo ATP synthase dimer [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(0) [mitochondrial inner membrane] (Homo sapiens)
        
        ATP synthase subunit c [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5MC1 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P05496 ATP5MC1

Gene Names

ATP5MC1, ATP5G1

Chain

transit peptide:1-61, chain:62-136

Reference Genes

BioGPS Gene:516 ATP5MC1

COSMIC (genes):ATP5MC1 ATP5MC1

CTD Gene:516 ATP5MC1

dbSNP Gene:516 ATP5MC1

ENSEMBL:ENSG00000159199 ATP5G1

HGNC:841 ATP5MC1

KEGG:hsa:516 ATP5MC1

Monarch:516 ATP5MC1

NCBI Gene:516 ATP5MC1

OMIM:603192 ATP5MC1

UCSC:P05496 ATP5MC1

Reference Transcript

Other Identifiers

11715988_x_at

16835483

208972_PM_s_at

208972_s_at

3725457

3725458

3725459

3725460

3725461

3725462

3725463

3725464

3725465

3725466

3725467

3725468

3725469

3725470

3725471

3725472

38076_at

516

8008132

88330_at

A_14_P124869

A_23_P164228

D13118_at

GE63257

GE79430

GO:0005215

GO:0005515

GO:0005739

GO:0005743

GO:0008289

GO:0015078

GO:0015986

GO:0016020

GO:0031966

GO:0033177

GO:0043226

GO:0045259

GO:0045263

GO:0055085

GO:0055086

GO:1901135

GO:1902600

HMNXSV003000858

HMNXSV003041879

ILMN_1712430

TC17000633.hg

TC17002260.hg

g5262506_3p_a_at

Participates

as a candidate of

Cargo of TIMM23 SORT [mitochondrial inner membrane] (Homo sapiens)

as a member of

ATP synthase subunit c [mitochondrial inner membrane] (Homo sapiens)

Other forms of this molecule

ATP5G1(1-136) [mitochondrial inner membrane]

ATP5G1(1-61) [mitochondrial matrix]

ATP5G1(1-136) [mitochondrial intermembrane space]

ATP5G1(1-136) [cytosol]

Inferred To

Atp5mc3 [mitochondrial inner membrane] (Mus musculus)

Atp5mc3 [mitochondrial inner membrane] (Rattus norvegicus)

LOC100519871 [mitochondrial inner membrane] (Sus scrofa)

ATP5MC3 [mitochondrial inner membrane] (Bos taurus)

ATP5MC3 [mitochondrial inner membrane] (Canis familiaris)

atp5mc1 [mitochondrial inner membrane] (Danio rerio)

ATP5G3 [mitochondrial inner membrane] (Gallus gallus)

ATP5MC1 [mitochondrial inner membrane] (Bos taurus)

ATP5MC1 [mitochondrial inner membrane] (Caenorhabditis elegans)

ATP5MC1 [mitochondrial inner membrane] (Canis familiaris)

ATP5MC1 [mitochondrial inner membrane] (Sus scrofa)

ATPsynC [mitochondrial inner membrane] (Drosophila melanogaster)

LOC610725 [mitochondrial inner membrane] (Canis familiaris)

Homologues of ATP5MC1 [mitochondrial inner membrane] (Bos taurus)

Homologues of ATP5MC1 [mitochondrial inner membrane] (Canis familiaris)

Homologues of ATP5MC1 [mitochondrial inner membrane] (Sus scrofa)

Cross References

ENSEMBL

ENSP00000348205, ENST00000393366, ENSP00000377033, ENST00000355938

OpenTargets

ENSG00000159199

HPA

ENSG00000159199-ATP5MC1

PRO

P05496

Pharos - Targets

P05496

HMDB Protein

HMDBP03265

PDB

8H9F, 8H9U, 8H9T, 8H9M, 8H9S, 8H9Q, 8H9J, 8KHF, 8H9V, 8KI3

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.527	2
UniProt:Q9H5K3 POMK	1	POMK [endoplasmic reticulum membrane] (R-HSA-8879120)	0.527	3
UniProt:P21217 FUT3	1	FUT3 [Golgi membrane] (R-HSA-5693934)	0.527	2