Fusogenic activation of gp41

Stable Identifier
Reaction [transition]
Homo sapiens
Related Species
Human immunodeficiency virus 1
gp41 N terminal fusion peptide released from viral membrane
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Fusion of HIV with target cell plasma membranes is mediated largely by the gp41 glycoprotein. This glycoprotein contains a stretch of strongly hydrophobic amino acids flanked by a series of polar amino acids at its N terminus. Subsequent to the second conformation change in gp120, the N-terminal fusion peptide of gp41 adopts a position which brings it into close proximity with the target cell plasma membrane. As gp41 is found in trimers within the viral membrane, the resulting structure of this conformational change is often referred to as a “prong”, in which three N-terminal peptides extend towards the target cell plasma membrane. The process of fusion begins at this time, with the N-terminus of gp41 inserting itself into the membrane of the target cell.
Literature References
PubMed ID Title Journal Year
2191297 Characterization of the fusion domain of the human immunodeficiency virus type 1 envelope glycoprotein gp41

Risser, R, Freed, EO, Myers, DJ

Proc Natl Acad Sci U S A 1990
8474172 Effects of amino acid changes in the extracellular domain of the human immunodeficiency virus type 1 gp41 envelope glycoprotein

Sodroski, J, Thali, M, Bergeron, L, Repke, H, Helseth, E, Cao, J

J Virol 1993
7745678 Requirement of N-terminal amino acid residues of gp41 for human immunodeficiency virus type 1-mediated cell fusion

Adams, O, Gehrmann, P, Klein, M, Schaal, H, Scheid, A

J Virol 1995
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
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