Reactome | Synthesis of full-length duplex viral DNA with a discontinuous plus strand

Synthesis of full-length duplex viral DNA with a discontinuous plus strand

Stable Identifier

R-HSA-164505

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Human immunodeficiency virus 1

Compartment

cytosol

ReviewStatus

5/5

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - HIV Life Cycle (Homo sapiens)
        
        Early Phase of HIV Life Cycle (Homo sapiens)
        
        Reverse Transcription of HIV RNA (Homo sapiens)
        
        Plus-strand DNA synthesis (Homo sapiens)
        
        Synthesis of full-length duplex viral DNA with a discontinuous plus strand (Homo sapiens)

General

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SVG | | PPTX | SBGN

Synthesis of full-length duplex viral DNA with a discontinuous plus strand

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After the second jump, elongation of the plus and minus strands continues. The elongation process requires strand displacement, which RT can mediate, at least in vitro (Huber et al. 1989; Hottiger et al. 1994; Rausch and Le Grice 2004). The final product is a blunt-ended linear duplex DNA with a discontinuity in its "plus" strand at the site of the cPPT sequence motif.

Literature References

PubMed ID	Title	Journal	Year
10723025	The HIV-1 reverse transcription (RT) process as target for RT inhibitors Jonckheere, H, Anne, J, De Clercq, E	Med Res Rev	2000
	Retroviruses Coffin, JM, Hughes, SH, Varmus, HE		1997