Synthesis of full-length duplex viral DNA with a discontinuous plus strand

Stable Identifier
R-HSA-164505
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

After the second jump, elongation of the plus and minus strands continues. The elongation process requires strand displacement, which RT can mediate, at least in vitro (Huber et al. 1989; Hottiger et al. 1994; Rausch and Le Grice 2004). The final product is a blunt-ended linear duplex DNA with a discontinuity in its "plus" strand at the site of the cPPT sequence motif.

Literature References
PubMed ID Title Journal Year
  Retroviruses

Coffin, JM, Hughes, SH, Varmus, HE

  1997
10723025 The HIV-1 reverse transcription (RT) process as target for RT inhibitors

Jonckheere, H, Anne, J, De Clercq, E

Med Res Rev 2000
Participants
Participates
Catalyst Activity

DNA-directed DNA polymerase activity of RTC with annealed complementary PBS seqments in +sssDNA and -strand DNA [cytosol]

Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Reviewed
Created
Cite Us!