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NDUFS8:2x4Fe-4S [mitochondrial matrix]
Stable Identifier
R-HSA-164295
Type
Complex
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
Complex I - 23 kDa subunit-2 x 4Fe-4S cluster complex
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUF subunits bind to form the IP subcomplex (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
NUBPL transfers 4Fe-4S to Complex I subunits (Homo sapiens)
NDUF:4Fe-4S subunits [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
NDUFS8:2x4Fe-4S [mitochondrial matrix] (Homo sapiens)
Participants
components
x 2
4Fe-4S [mitochondrial matrix]
NDUFS8 [mitochondrial matrix]
(Homo sapiens)
Participates
as a component of
IP subcomplex [mitochondrial matrix] (Homo sapiens)
Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
as an input of
NDUF subunits bind to form the IP subcomplex (Homo sapiens)
as a member of
NDUF:4Fe-4S subunits [mitochondrial matrix] (Homo sapiens)
Inferred To
NDUFS8:2x4Fe-4S [mitochondrial matrix]
(Bos taurus)
NDUFS8:2x4Fe-4S [mitochondrial matrix]
(Caenorhabditis elegans)
NDUFS8:2x4Fe-4S [mitochondrial matrix]
(Canis familiaris)
NDUFS8:2x4Fe-4S [mitochondrial matrix]
(Danio rerio)
NDUFS8:2x4Fe-4S [mitochondrial matrix]
(Dictyostelium discoideum)
NDUFS8:2x4Fe-4S [mitochondrial matrix]
(Drosophila melanogaster)
NDUFS8:2x4Fe-4S [mitochondrial matrix]
(Gallus gallus)
NDUFS8:2x4Fe-4S [mitochondrial matrix]
(Mus musculus)
NDUFS8:2x4Fe-4S [mitochondrial matrix]
(Rattus norvegicus)
NDUFS8:2x4Fe-4S [mitochondrial matrix]
(Sus scrofa)
NDUFS8:2x4Fe-4S [mitochondrial matrix]
(Xenopus tropicalis)
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