Reactome | PRKAG2 [nucleoplasm]

PRKAG2 [nucleoplasm]

Stable Identifier

R-HSA-164130

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

AMPK gamma2

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        AMPK phosphorylates TP53 (Homo sapiens)
        
        Activated AMPK heterotrimer [nucleoplasm] (Homo sapiens)
        
        AMPK gamma [nucleoplasm] (Homo sapiens)
        
        PRKAG2 [nucleoplasm] (Homo sapiens)

Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Activation of PPARGC1A (PGC-1alpha) by phosphorylation (Homo sapiens)
    - AMPK phosphorylates PPARGC1A (Homo sapiens)
      - p-AMPK heterotrimer:AMP [nucleoplasm] (Homo sapiens)
        
        p-AMPK heterotrimer [nucleoplasm] (Homo sapiens)
        
        AMPK gamma [nucleoplasm] (Homo sapiens)
        
        PRKAG2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UGJ0 PRKAG2

Gene Names

PRKAG2

Chain

chain:1-569

Reference Genes

BioGPS Gene:51422 Q9UGJ03

COSMIC (genes):PRKAG2 PRKAG2

CTD Gene:51422 Q9UGJ03

dbSNP Gene:51422 PRKAG2

ENSEMBL:ENSG00000106617 PRKAG2

HGNC:9386 Q9UGJ03

KEGG:hsa:51422 Q9UGJ03

Monarch:51422 Q9UGJ03

NCBI Gene:51422 Q9UGJ03

OMIM:602743 Q9UGJ03

UCSC:Q9UGJ0 Q9UGJ03

Reference Transcript

Participates

as a component of

as a member of

AMPK gamma [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PRKAG2 [cytosol]

PRKAG2 [endoplasmic reticulum lumen]

Inferred To

prkag [nucleoplasm] (Dictyostelium discoideum)

SNF4Agamma [nucleoplasm] (Drosophila melanogaster)

prkag2b [nucleoplasm] (Danio rerio)

cbs2 [nucleoplasm] (Schizosaccharomyces pombe)

SNF4 [nucleoplasm] (Saccharomyces cerevisiae)

PRKAG2 [nucleoplasm] (Bos taurus)

PRKAG2 [nucleoplasm] (Canis familiaris)

PRKAG2 [nucleoplasm] (Sus scrofa)

Prkag2 [nucleoplasm] (Mus musculus)

Prkag2 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001291456.1, NP_001393953.1, NP_077747.1, NP_001291460.1, XP_016867759.1, NP_057287.2, NP_001035723.1

Guide to Pharmacology - Targets

1546

OpenTargets

ENSG00000106617

ENSEMBL

ENST00000418337, ENSP00000376549, ENST00000476632, ENSP00000419493, ENSP00000387386, ENSP00000498796, ENSP00000499025, ENSP00000499103, ENST00000287878, ENST00000651764, ENST00000652159, ENST00000651378, ENSG00000106617, ENST00000392801, ENSP00000287878

HPA

ENSG00000106617-PRKAG2

GeneCards

PRKAG2

PRO

Q9UGJ0

Pharos - Targets

Q9UGJ0

Orphanet

PRKAG2

GlyGen

Q9UGJ0

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54646 PRKAA2	5	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) p-T172-PRKAA2 [endoplasmic reticulum lumen] (R-HSA-9931258) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.643	6
UniProt:Q13501 SQSTM1	7	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967)	0.556	3

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