GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6)

Stable Identifier
R-HSA-163810
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
pro-GAS6, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-GAS6 + 11 H2O + 11 vitamin K epoxide
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GGCX (gamma glutamyl carboxylase) in the endoplasmic reticulum gamma-carboxylates eleven glutamate residues on GAS6(31-691) (pro-GAS6). MK4 (vitamin K hydroquinone) is oxidized to MK4 epoxide in the process. The details of the gamma-carboxylation of GAS6 have not been determined directly, but are inferred from those worked out for protein S (Manfioletti et al. 1993).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
gamma-glutamyl carboxylase activity of GGCX [endoplasmic reticulum membrane]
Physical Entity
Activity
Inferred From
Authored
Created
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