GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6)

Stable Identifier
R-HSA-163810
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
Synonyms
pro-GAS6, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-GAS6 + 11 H2O + 11 vitamin K epoxide
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
GGCX (gamma glutamyl carboxylase) in the endoplasmic reticulum gamma-carboxylates eleven glutamate residues on GAS6(31-691) (pro-GAS6). MK4 (vitamin K hydroquinone) is oxidized to MK4 epoxide in the process. The details of the gamma-carboxylation of GAS6 have not been determined directly, but are inferred from those worked out for protein S (Manfioletti et al. 1993).
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

gamma-glutamyl carboxylase activity of GGCX [endoplasmic reticulum membrane]

Physical Entity
GGCX [endoplasmic reticulum membrane] (Homo sapiens)
Activity
gamma-glutamyl carboxylase activity (GO:0008488)
Inferred From
GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Homo sapiens)
Authored
D'Eustachio, P  (2005-05-08)
Created
D'Eustachio, P  (2005-05-08)
Cite Us!