Activation of PP2A by Xylulose-5-phosphate

Stable Identifier
R-HSA-163769
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Activation of PP2A by Xylulose-5-phosphate
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Xylulose-5-phosphate binds to Protein phosphatase 2A (PP2A), activating it. This regulatory step may be the crucial physiological link explaining the coordinately increased rates of glycolysis and lipogenesis generally observed in individuals consuming high-carbohydrate diets.

Literature References
PubMed ID Title Journal Year
12721358 A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis

Veech, RL

Proc Natl Acad Sci U S A 2003
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
XY5P [cytosol]
Inferred From
Activation of rPP2A by Xylulose-5-phosphate (Rattus norvegicus)
Authored
Gopinathrao, G  (2005-05-14)
Created
Gopinathrao, G  (2005-05-06)
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