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PP2A-mediated dephosphorylation of key metabolic factors
Stable Identifier
R-HSA-163767
DOI
10.3180/REACT_705.2
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
,
nucleoplasm
ReviewStatus
5/5
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Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
PP2A-mediated dephosphorylation of key metabolic factors (Homo sapiens)
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A member of the PP2A family of phosphatases dephosphorylates both cytosolic and nuclear forms of ChREBP (Carbohydrate Response Element Binding Protein). In the nucleus, dephosphorylated ChREBP complexes with MLX protein and binds to ChRE sequence elements in chromosomal DNA, activating transcription of genes involved in glycolysis and lipogenesis. The phosphatase is activated by Xylulose-5-phosphate, an intermediate of the pentose phosphate pathway (Kabashima et al. 2003). The rat enzyme has been purified to homogeneity and shown by partial amino acid sequence analysis to differ from previously described PP2A phosphatases (Nishimura and Uyeda 1995) - the human enzyme has not been characterized.
Literature References
PubMed ID
Title
Journal
Year
12721358
A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis
Veech, RL
Proc Natl Acad Sci U S A
2003
Participants
Events
Dephosphorylation of pChREBP (Ser 196) by PP2A
(Homo sapiens)
Dephosphorylation of pChREBP (Ser 556) by PP2A
(Homo sapiens)
Dephosphorylation of pChREBP (Thr 666) by PP2A
(Homo sapiens)
Dephosphorylation of phosphoPFKFB1 by PP2A complex
(Homo sapiens)
Participates
as an event of
Integration of energy metabolism (Homo sapiens)
Event Information
Go Biological Process
regulation of gene expression (0010468)
Authored
Gopinathrao, G (2005-05-13)
Created
Gopinathrao, G (2005-05-06)
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