Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-S33-PFKFB1 [cytosol]
Stable Identifier
R-HSA-163749
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
phosphoPFKFB1, pPF2k-Pase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
PKA-mediated phosphorylation of key metabolic factors (Homo sapiens)
Phosphorylation of PF2K-Pase by PKA catalytic subunit (Homo sapiens)
phosphoPFKFB1 dimer [cytosol] (Homo sapiens)
p-S33-PFKFB1 [cytosol] (Homo sapiens)
PP2A-mediated dephosphorylation of key metabolic factors (Homo sapiens)
Dephosphorylation of phosphoPFKFB1 by PP2A complex (Homo sapiens)
phosphoPFKFB1 dimer [cytosol] (Homo sapiens)
p-S33-PFKFB1 [cytosol] (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Glycolysis (Homo sapiens)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Homo sapiens)
Dephosphorylation of phosphoPFKFB1 by PP2A complex (Homo sapiens)
phosphoPFKFB1 dimer [cytosol] (Homo sapiens)
p-S33-PFKFB1 [cytosol] (Homo sapiens)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Homo sapiens)
phosphoPFKFB1 dimer [cytosol] (Homo sapiens)
p-S33-PFKFB1 [cytosol] (Homo sapiens)
Phosphorylation of PF2K-Pase by PKA catalytic subunit (Homo sapiens)
phosphoPFKFB1 dimer [cytosol] (Homo sapiens)
p-S33-PFKFB1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16118 PFKFB1
Gene Names
PFKFB1, F6PK, PFRX
Chain
initiator methionine:, chain:2-471
Reference Genes
BioGPS Gene:5207 PFKFB1
COSMIC (genes):PFKFB1 PFKFB1
CTD Gene:5207 PFKFB1
dbSNP Gene:5207 PFKFB1
ENSEMBL:ENSG00000158571 PFKFB1
HGNC:8872 PFKFB1
KEGG:hsa:5207 PFKFB1
Monarch:5207 PFKFB1
NCBI Gene:5207 PFKFB1
OMIM:311790 PFKFB1
UCSC:P16118 PFKFB1
Reference Transcript
RefSeq:NM_001271805.1 PFKFB1
RefSeq:NM_002625.3 PFKFB1
RefSeq:NM_001271804.1 PFKFB1
Other Identifiers
11750181_a_at
17111501
207537_PM_at
207537_at
33980_at
4009814
4009815
4009816
4009817
4009821
4009823
4009824
4009825
4009828
4009829
4009831
4009832
4009833
4009834
4009835
4009836
4009838
4009839
4009844
5207
8173120
A_24_P203106
GE59777
GO:0000166
GO:0003824
GO:0003873
GO:0004331
GO:0005515
GO:0005524
GO:0005829
GO:0005975
GO:0006000
GO:0006003
GO:0006091
GO:0006094
GO:0006096
GO:0016301
GO:0016740
GO:0016787
GO:0019900
GO:0031100
GO:0032868
GO:0033762
GO:0042594
GO:0042802
GO:0043540
GO:0046835
GO:0048856
GO:0051384
GO:0051591
GO:0055086
GO:0070095
GO:1901135
GO:1904539
GO:1904540
HMNXSV003017916
ILMN_1741600
PH_hs_0001257
PH_hs_0025955
TC0X001076.hg
X52638_at
g4505744_3p_at
Participates
as a component of
phosphoPFKFB1 dimer [cytosol] (Homo sapiens)
Other forms of this molecule
PFKFB1 [cytosol]
Inferred To
phospho-p-S33-PFKFB1 [cytosol]
(Bos taurus)
phospho-p-S33-PFKFB1 [cytosol]
(Caenorhabditis elegans)
phospho-p-S33-PFKFB1 [cytosol]
(Canis familiaris)
phospho-p-S33-PFKFB1 [cytosol]
(Dictyostelium discoideum)
phospho-p-S33-PFKFB1 [cytosol]
(Drosophila melanogaster)
phospho-p-S33-PFKFB1 [cytosol]
(Gallus gallus)
phospho-p-S33-PFKFB1 [cytosol]
(Mus musculus)
phospho-p-S33-PFKFB1 [cytosol]
(Rattus norvegicus)
phospho-p-S33-PFKFB1 [cytosol]
(Saccharomyces cerevisiae)
phospho-p-S33-PFKFB1 [cytosol]
(Schizosaccharomyces pombe)
phospho-p-S33-PFKFB1 [cytosol]
(Sus scrofa)
Homologues of p-S33-PFKFB1 [cytosol]
(Caenorhabditis elegans)
Homologues of p-S33-PFKFB1 [cytosol]
(Dictyostelium discoideum)
Homologues of p-S33-PFKFB1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of p-S33-PFKFB1 [cytosol]
(Schizosaccharomyces pombe)
Modified Residues
Name
O-phospho-L-serine at 33
Coordinate
33
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
ENSEMBL
ENST00000545676
,
ENST00000375006
,
ENSP00000364145
,
ENSP00000444074
OpenTargets
ENSG00000158571
HPA
ENSG00000158571-PFKFB1
ZINC target
P16118
PRO
P16118
Pharos - Targets
P16118
GlyGen
P16118
HMDB Protein
HMDBP00799
PDB
1K6M
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35557 GCK
8
GCK [cytosol]
(R-HSA-450094)
GCK [nucleoplasm]
(R-HSA-450102)
GCK G229R [cytosol]
(R-HSA-5621863)
GCK T228M [cytosol]
(R-HSA-5621852)
GCK E279* [cytosol]
(R-HSA-5621903)
GCK E339K [cytosol]
(R-HSA-5621913)
GCK G261R [cytosol]
(R-HSA-5621848)
GCK A378T [cytosol]
(R-HSA-5621850)
0.558
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text