PKA activation

Stable Identifier
R-HSA-163615
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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PKA activation
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A number of inactive tetrameric PKA holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. When cAMP binds to two specific binding sites on the regulatory subunits, these undergo a conformational change that causes the dissociation of a dimer of regulatory subunits bound to four cAMP from two monomeric, catalytically active PKA subunits.
Literature References
PubMed ID Title Journal Year
2165385 cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes

Taylor, SS, Buechler, JA, Yonemoto, W

Annu Rev Biochem 1990
Participants
Events
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as an event of
Event Information
Go Biological Process
activation of protein kinase A activity (0034199)
Orthologous Events
PKA activation (Bos taurus)
PKA activation (Caenorhabditis elegans)
PKA activation (Canis familiaris)
PKA activation (Danio rerio)
PKA activation (Dictyostelium discoideum)
PKA activation (Drosophila melanogaster)
PKA activation (Gallus gallus)
PKA activation (Mus musculus)
PKA activation (Rattus norvegicus)
PKA activation (Saccharomyces cerevisiae)
PKA activation (Schizosaccharomyces pombe)
PKA activation (Sus scrofa)
PKA activation (Xenopus tropicalis)
Authored
Jassal, B  (2004-03-31)
Le Novere, N  (2004-03-31)
Reviewed
D'Eustachio, P  (2024-03-04)
Castagnoli, L  (2008-11-06)
D'Eustachio, P  (2024-01-29)
Created
Schmidt, EE  (2005-05-03)
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