2 phosphorylated HSL monomers -> phosphorylated HSL dimer

Stable Identifier
R-HSA-163602
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

While both monomeric and homodimeric forms of rat HSL protein have been detected, the predominant species, and the one with substantially greater catalytic activity when activated by phosphorylation, is the homodimer so HSL-mediated lipolysis is annotated in Reactome with dimeric phosphorylated enzyme as the catalyst. Phosphorylation appears to be required for dimerization to proceed (Shen et al. 2000).

Dimerization of human HSL has not been studied in detail, so the human reaction is inferred from the well-studied rat one.

Participants
Participant Of
Inferred From
Authored
Created