Reactome | 2 phosphorylated HSL monomers -> phosphorylated HSL dimer

2 phosphorylated HSL monomers -> phosphorylated HSL dimer

Stable Identifier

R-HSA-163602

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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2 phosphorylated HSL monomers -> phosphorylated HSL dimer

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While both monomeric and homodimeric forms of rat HSL protein have been detected, the predominant species, and the one with substantially greater catalytic activity when activated by phosphorylation, is the homodimer so HSL-mediated lipolysis is annotated in Reactome with dimeric phosphorylated enzyme as the catalyst. Phosphorylation appears to be required for dimerization to proceed (Shen et al. 2000).

Dimerization of human HSL has not been studied in detail, so the human reaction is inferred from the well-studied rat one.

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