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FABP4 [lipid droplet]
Stable Identifier
R-HSA-163428
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lipid droplet
Synonyms
fatty acid binding protein, adipocyte
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of FABP4 (aP2) (Homo sapiens)
FABP4 [lipid droplet] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Homo sapiens)
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes (Homo sapiens)
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (Homo sapiens)
FABP4 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
FABP4 [lipid droplet] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Triglyceride metabolism (Homo sapiens)
Triglyceride catabolism (Homo sapiens)
cholesterol ester + H2O -> cholesterol + fatty acid (Homo sapiens)
phosphorylated HSL dimer:FABP4 complex [lipid droplet] (Homo sapiens)
FABP4 [lipid droplet] (Homo sapiens)
diacylglycerol + H2O -> 2-acylglycerol + fatty acid (Homo sapiens)
phosphorylated HSL dimer:FABP4 complex [lipid droplet] (Homo sapiens)
FABP4 [lipid droplet] (Homo sapiens)
phosphorylated HSL dimer + FABP4 -> phosphorylated HSL dimer:FABP4 complex (Homo sapiens)
FABP4 [lipid droplet] (Homo sapiens)
phosphorylated HSL dimer:FABP4 complex [lipid droplet] (Homo sapiens)
FABP4 [lipid droplet] (Homo sapiens)
triacylglycerol + H2O -> diacylglycerol + fatty acid (Homo sapiens)
phosphorylated HSL dimer:FABP4 complex [lipid droplet] (Homo sapiens)
FABP4 [lipid droplet] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15090 FABP4
Gene Names
FABP4
Chain
initiator methionine:, chain:2-132
Reference Genes
BioGPS Gene:2167 FABP4
COSMIC (genes):FABP4 FABP4
CTD Gene:2167 FABP4
dbSNP Gene:2167 FABP4
ENSEMBL:ENSG00000170323 FABP4
HGNC:3559 FABP4
Monarch:2167 FABP4
NCBI Gene:2167 FABP4
OMIM:600434 FABP4
UCSC:P15090 FABP4
Reference Transcript
RefSeq:NM_001442.2 FABP4
Other Identifiers
11716697_at
17078592
203980_PM_at
203980_at
2167
235978_PM_at
235978_at
3142382
3142383
3142384
3142386
3142387
3142388
3142389
3142393
3142394
38430_at
76163_at
8151532
A_23_P8820
GE79242
GO:0005215
GO:0005324
GO:0005504
GO:0005634
GO:0005737
GO:0005811
GO:0005829
GO:0006355
GO:0008289
GO:0009617
GO:0015908
GO:0015909
GO:0030154
GO:0036041
GO:0042632
GO:0043226
GO:0045892
GO:0050729
GO:0050872
GO:0050873
GO:0051427
GO:0070062
GO:0071285
GO:0071356
GO:0120162
HMNXSV003028023
Hs.117687.0.A1_3p_at
ILMN_1773006
J02874_at
PH_hs_0018925
TC08001365.hg
g4557578_3p_at
Participates
as an input of
phosphorylated HSL dimer + FABP4 -> phosphorylated HSL dimer:FABP4 complex (Homo sapiens)
as a component of
phosphorylated HSL dimer:FABP4 complex [lipid droplet] (Homo sapiens)
as an output of
FABP4 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
Expression of FABP4 (aP2) (Homo sapiens)
Other forms of this molecule
FABP4 [nucleoplasm]
FABP4 [cytosol]
Cross References
ZINC - World Drugs
FABP4_HUMAN
Guide to Pharmacology - Targets
2534
OpenTargets
ENSG00000170323
ENSEMBL
ENSP00000256104
,
ENST00000256104
ZINC - FDA approved
FABP4_HUMAN
ZINC - Substances
FABP4_HUMAN
ZINC - Biogenic
FABP4_HUMAN
ZINC target
P15090
PRO
P15090
PDB
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
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,
7FZY
,
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,
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,
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,
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,
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,
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,
7G0I
,
7G0A
,
7G18
,
5D48
,
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,
7FWB
,
7FY9
,
7FZJ
,
7FW3
,
3FR5
,
7FZ1
,
7FYV
,
7FX8
,
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,
7FXJ
,
7FW4
,
7FWH
,
6LJV
,
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,
7FZ6
,
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ZINC - Investigational
FABP4_HUMAN
ZINC - Metabolites
FABP4_HUMAN
HPA
ENSG00000170323-FABP4
Pharos - Targets
P15090
ZINC - Predictions - Purchasable
FABP4_HUMAN
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08670 VIM
11
Vimentin [lysosomal lumen]
(R-HSA-9659977)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [late endosome lumen]
(R-HSA-9660019)
VIM [cytosol]
(R-HSA-201600)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(2-85) [cytosol]
(R-HSA-350264)
0.553
2
UniProt:P43026 GDF5
1
GDF5(28-501) [extracellular region]
(R-HSA-2396129)
0.527
2
UniProt:Q9UMX2 OAZ3
1
OAZ3 [cytosol]
(R-HSA-350586)
0.527
2
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