Reactome | TFAM binds to mitochondrial promoters

TFAM binds to mitochondrial promoters

Stable Identifier

R-HSA-163310

Type

Reaction [binding]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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Studies of human LSP have revealed that a minimal DNA fragment corresponding to position -28 to +16 relative to the transcription initiation site is able to support transcription initiation in a mitochondrial extract (Chang and Clayton, 1984). TFAM interacts directly with nucleotides between positions -35 and -17 (Fisher et al., 1987), and the exact distance between the TFAM-binding site and the transcription start site is essential for promoter activity (Dairaghi et al., 1995).

Literature References

PubMed ID	Title	Journal	Year
3594571	Promoter selection in human mitochondria involves binding of a transcription factor to orientation-independent upstream regulatory elements Topper, JN, Fisher, RP	Cell	1987