ULK1 phosphorylates AMBRA1:Beclin-1 complex

Stable Identifier
R-HSA-1632857
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Upon autophagy induction, ULK1 phosphorylates AMBRA1, which leads to the release of the Beclin-1 complex from the dynein motor complex (Di Bartolomeo et al. 2010).

Literature References
PubMed ID Title Journal Year
20921139 The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

Di Bartolomeo, S, Corazzari, M, Nazio, F, Oliverio, S, Lisi, G, Antonioli, M, Pagliarini, V, Matteoni, S, Fuoco, C, Giunta, L, D'Amelio, M, Nardacci, R, Romagnoli, A, Piacentini, M, Cecconi, F, Fimia, GM

J Cell Biol 2010
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created