Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Alignment Of The RNA Template On The Telomeric Chromosome End
Stable Identifier
R-HSA-163099
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere Extension By Telomerase (Homo sapiens)
Alignment Of The RNA Template On The Telomeric Chromosome End (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In vitro studies of telomerase complexes derived from multiple organisms indicate that at least two types of interactions are important for telomerase RNP catalytic site alignment at the 3' G-rich single-strand telomere end. In one interaction, an alignment region in hTERC base-pairs with the 3' G-rich single-strand telomeric DNA end to form an RNA-DNA hybrid, which positions the template adjacent to the 3' end of the telomere. In a second interaction, a portion of hTERT is proposed to interact with the DNA 5' of the telomerase RNA/DNA primer hybrid (Harrington and Greider 1991; Morin 1991; Moriarty et al. 2005), which is important for the catalytic rate (Lee and Blackburn, 1993) and presumably allows telomerase to maintain contact with the chromosome during the translocation step. How the anchor site binding and template hybridization are coordinated is not known.
Literature References
PubMed ID
Title
Journal
Year
15189140
Regulation of telomerase by telomeric proteins
Smogorzewska, A
,
de Lange, T
Annu Rev Biochem
2004
Participants
Input
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm]
(Homo sapiens)
Output
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Telomere Extension By Telomerase (Homo sapiens)
Event Information
Go Biological Process
telomere maintenance via telomerase (0007004)
Orthologous Events
Recruitment of telomerase RNP to a telomeric chromosome end (Gallus gallus)
Alignment Of The RNA Template On The Telomeric Chromosome End (Bos taurus)
Alignment Of The RNA Template On The Telomeric Chromosome End (Canis familiaris)
Alignment Of The RNA Template On The Telomeric Chromosome End (Gallus gallus)
Alignment Of The RNA Template On The Telomeric Chromosome End (Mus musculus)
Alignment Of The RNA Template On The Telomeric Chromosome End (Rattus norvegicus)
Alignment Of The RNA Template On The Telomeric Chromosome End (Sus scrofa)
Authored
Blackburn, EH (2006-03-10)
Seidel, J (2006-03-10)
Reviewed
Hayashi, MT (2020-04-29)
Price, C (2006-07-13)
Created
Gillespie, ME (2005-04-18)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text