Reactome | STAG2 [nucleoplasm]

STAG2 [nucleoplasm]

Stable Identifier

R-HSA-163046

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SA2, Cohesin subunit SA-2, SCC3 homolog 2

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of DNA damage response and repair proteins (Homo sapiens)
        
        SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Homo sapiens)
        
        Cohesin Complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)

Reproduction (Homo sapiens)

- Meiosis (Homo sapiens)
  - Meiotic synapsis (Homo sapiens)
    - ATR Kinase is recruited to unsynapsed regions (Homo sapiens)
      - Synaptonemal Complex:BRCA1 [nucleoplasm] (Homo sapiens)
        
        Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
      - Synaptonemal Complex:BRCA1:ATR [nucleoplasm] (Homo sapiens)
        
        Synaptonemal Complex:BRCA1 [nucleoplasm] (Homo sapiens)
        
        Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
    - ATR phosphorylates Histone H2A.X at unsynapsed regions (Homo sapiens)
      - Synaptonemal Complex:BRCA1:ATR [nucleoplasm] (Homo sapiens)
        
        Synaptonemal Complex:BRCA1 [nucleoplasm] (Homo sapiens)
        
        Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
      - Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
      - Unsynapsed chromatin with gamma-H2A.x [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
    - BRCA1 is recruited to unsynapsed regions (Homo sapiens)
      - Synaptonemal Complex:BRCA1 [nucleoplasm] (Homo sapiens)
        
        Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
      - Unsynapsed chromatin [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
    - Formation of axial/lateral elements of Synaptonemal Complex (Homo sapiens)
      - Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
      - Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
    - Synapsis (Homo sapiens)
      - Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
      - Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
    - Telomeres cluster at the nuclear membrane (Homo sapiens)
      - Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)
      - Telomere Attachment Plate [nuclear envelope] (Homo sapiens)
        
        Axial-Lateral Element of Synaptonemal Complex [nucleoplasm] (Homo sapiens)
        
        Meiotic Cohesin complex [nucleoplasm] (Homo sapiens)
        
        STAG2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8N3U4 STAG2

Gene Names

STAG2, SA2

Chain

chain:1-1231

Reference Genes

BioGPS Gene:10735 STAG2

COSMIC (genes):STAG2 STAG2

CTD Gene:10735 STAG2

dbSNP Gene:10735 STAG2

ENSEMBL:ENSG00000101972 STAG2

ENSEMBL_homo_sapiens_GENE:ENSG00000101972.20 STAG2

HGNC:11355 STAG2

KEGG Gene (Homo sapiens):10735 STAG2

Monarch:10735 STAG2

NCBI Gene:10735 STAG2

OMIM:300826 STAG2

UCSC:Q8N3U4 STAG2

Reference Transcript

Other Identifiers

10735

11731107_a_at

11731108_s_at

11739903_a_at

11743520_a_at

17106739

207983_PM_s_at

207983_s_at

209022_PM_at

209022_at

209023_PM_s_at

209023_s_at

34709_r_at

3989716

3989717

3989718

3989720

3989722

3989723

3989724

3989726

3989727

3989728

3989731

3989748

3989749

3989750

3989751

3989753

3989755

3989756

3989757

3989759

3989761

3989762

3989763

3989764

3989765

3989766

3989767

3989768

3989769

3989770

3989771

3989773

3989774

3989775

3989776

3989779

3989780

3989781

3989782

3989783

3989784

3989785

3989787

3989788

3989792

3989793

3989797

3989798

3989799

48629_s_at

48630_r_at

64266_at

8169750

A_24_P66125

A_33_P3304293

GE528843

GE85697

GO:0000278

GO:0000775

GO:0000785

GO:0001650

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005829

GO:0005856

GO:0007010

GO:0007049

GO:0007059

GO:0007062

GO:0008278

GO:0016020

GO:0016363

GO:0022414

GO:0030892

GO:0034087

GO:0043226

GO:0051301

GO:0051321

GO:0090307

GO:0097431

GO:0140014

HMNXSV003015521

Hs.8217.1.A2_3p_at

ILMN_1782609

ILMN_2293677

ILMN_2333708

PH_hs_0000880

TC0X000606.hg

TC0X001859.hg

g5730068_3p_a_at

Participates

as a component of

Other forms of this molecule

monoSUMO1-K-STAG2 [nucleoplasm]

p-STAG2 [chromosome, centromeric region]

p-STAG2 [cytosol]

p-STAG2 [chromosome]

STAG2 [cytosol]

STAG2 [chromosome]

STAG2 [chromosome, centromeric region]

Inferred To

psc3 [nucleoplasm] (Schizosaccharomyces pombe)

Cohesin subunit SA-2 [nucleoplasm] (Mus musculus)

stag2b [nucleoplasm] (Danio rerio)

Homologues of STAG2 [nucleoplasm] (Drosophila melanogaster)

Homologues of STAG2 [nucleoplasm] (Schizosaccharomyces pombe)

SA1 [nucleoplasm] (Drosophila melanogaster)

Stag2 [nucleoplasm] (Rattus norvegicus)

scc-3 [nucleoplasm] (Caenorhabditis elegans)

IRR1 [nucleoplasm] (Saccharomyces cerevisiae)

SA2 [nucleoplasm] (Drosophila melanogaster)

STAG2 [nucleoplasm] (Bos taurus)

STAG2 [nucleoplasm] (Canis familiaris)

STAG2 [nucleoplasm] (Dictyostelium discoideum)

STAG2 [nucleoplasm] (Gallus gallus)

STAG2 [nucleoplasm] (Sus scrofa)

rec11 [nucleoplasm] (Schizosaccharomyces pombe)

stag2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

XP_005262416.1, NP_006594.3, XP_005262417.1, XP_005262415.1, NP_001036214.1, XP_016884723.1, XP_016884722.1, NP_001269347.1, XP_005262418.1, XP_006724790.1, NP_001036215.1, XP_005262414.1, XP_011529555.1, XP_016884721.1, NP_001036216.1

OpenTargets

ENSG00000101972

GeneCards

Q8N3U4

HPA

ENSG00000101972-STAG2

Ensembl

ENST00000687852, ENSP00000360186, ENSP00000360187, ENSP00000360199, ENST00000371160, ENSP00000509048, ENST00000371144, ENSP00000360202, ENST00000371145, ENSP00000218089, ENSG00000101972, ENST00000218089, ENST00000371157

PRO

Q8N3U4

Pharos - Targets

Q8N3U4

Orphanet

24951

PDB

4PK7, 7ZJS, 4PJU, 6QNX, 4PJW

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60216 RAD21	14	monoSUMO1-K-RAD21 [nucleoplasm] (R-HSA-3108183) p-S454-RAD21 [cytosol] (R-HSA-2500310) p-S454-RAD21 [chromosome] (R-HSA-2485164) RAD21 [cytosol] (R-HSA-2484795) p-S454-RAD21(451-631) [cytosol] (R-HSA-2500309) RAD21(173-450) [cytosol] (R-HSA-2500308) RAD21(1-172) [cytosol] (R-HSA-2484901) RAD21(173-450) [chromosome, centromeric region] (R-HSA-2500296) p-S454-RAD21(451-631) [chromosome, centromeric region] (R-HSA-2467790) RAD21(1-172) [chromosome, centromeric region] (R-HSA-2467793) p-S454-RAD21 [chromosome, centromeric region] (R-HSA-2485163) RAD21 [chromosome] (R-HSA-1638775) RAD21 [nucleoplasm] (R-HSA-163042) RAD21 [chromosome, centromeric region] (R-HSA-2466012)	0.966	22
UniProt:Q7Z5K2 WAPL	4	WAPAL [cytosol] (R-HSA-2484802) WAPAL [chromosome] (R-HSA-2577090) WAPAL [chromosome, centromeric region] (R-HSA-2577088) WAPAL [nucleoplasm] (R-HSA-2466355)	0.922	14
UniProt:Q9CPY3	6	phospho-Cdca5 [chromosome] (R-MMU-2468266) phospho-Cdca5 [cytosol] (R-MMU-2484804) phospho-Cdca5 [chromosome, centromeric region] (R-MMU-2468269) Cdca5 [chromosome] (R-MMU-2468149) Cdca5 [chromosome, centromeric region] (R-MMU-2468260) Cdca5 [nucleoplasm] (R-MMU-2466357)	0.669	3
UniProt:Q96FF9 CDCA5	6	p-S21,S75,T159-CDCA5 [chromosome] (R-HSA-2468266) p-S21,S75,T159-CDCA5 [cytosol] (R-HSA-2484804) p-S21,S75,T159-CDCA5 [chromosome, centromeric region] (R-HSA-2468269) CDCA5 [chromosome] (R-HSA-2468149) CDCA5 [chromosome, centromeric region] (R-HSA-2468260) CDCA5 [nucleoplasm] (R-HSA-2466357)	0.643	5
UniProt:Q9NP77 SSU72	1	SSU72 [nucleoplasm] (R-HSA-6814915)	0.577	4

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