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KDM6B [nucleoplasm]
Stable Identifier
R-HSA-1629833
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Lysine-specific demethylase 6B, JMJD3, JmjC domain-containing protein 3, Jumonji domain-containing protein 3, Lysine demethylase 6B, KIAA0346
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
AP-1 complex stimulates KDM6B transcription (Homo sapiens)
KDM6B [nucleoplasm] (Homo sapiens)
Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription (Homo sapiens)
KDM6B:Fe2+ [nucleoplasm] (Homo sapiens)
KDM6B [nucleoplasm] (Homo sapiens)
KDM6B binds iron (Homo sapiens)
KDM6B [nucleoplasm] (Homo sapiens)
KDM6B:Fe2+ [nucleoplasm] (Homo sapiens)
KDM6B [nucleoplasm] (Homo sapiens)
KDM6B demethylates H3K27me3 on p16INK4A promoter (Homo sapiens)
KDM6B:Fe2+ [nucleoplasm] (Homo sapiens)
KDM6B [nucleoplasm] (Homo sapiens)
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HDMs demethylate histones (Homo sapiens)
KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Homo sapiens)
KDM6A,KDM6B,KDM6C,KDM7A [nucleoplasm] (Homo sapiens)
KDM6B [nucleoplasm] (Homo sapiens)
KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Homo sapiens)
KDM6A,KDM6B,KDM6C,KDM7A [nucleoplasm] (Homo sapiens)
KDM6B [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Maternal to zygotic transition (MZT) (Homo sapiens)
Chromatin modifications during the maternal to zygotic transition (MZT) (Homo sapiens)
KDM6B (JMJD3) demethylates histone H3 trimethyllysine-27 (H3K27me3) (Homo sapiens)
KDM6B:Fe2+ [nucleoplasm] (Homo sapiens)
KDM6B [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15054 KDM6B
Gene Names
KDM6B, JMJD3, KIAA0346
Chain
chain:1-1643
Reference Genes
BioGPS Gene:23135 KDM6B
COSMIC (genes):KDM6B KDM6B
CTD Gene:23135 KDM6B
dbSNP Gene:23135 KDM6B
ENSEMBL:ENSG00000132510 KDM6B
ENSEMBL_homo_sapiens_GENE:ENSG00000132510.11 KDM6B
HGNC:29012 KDM6B
Monarch:23135 KDM6B
NCBI Gene:23135 KDM6B
OMIM:611577 KDM6B
UCSC:O15054 KDM6B
Reference Transcript
RefSeq:XM_005256552.4 KDM6B
RefSeq:XM_011523752.2 KDM6B
RefSeq:XM_005256549.3 KDM6B
RefSeq:XM_005256551.3 KDM6B
RefSeq:NM_001348716.1 KDM6B
RefSeq:XM_011523750.2 KDM6B
RefSeq:NM_001080424.2 KDM6B
RefSeq:XM_005256550.4 KDM6B
RefSeq:XM_006721483.3 KDM6B
Other Identifiers
11724642_at
11743673_at
11743674_x_at
1556066_PM_at
1556066_at
1556067_PM_a_at
1556067_a_at
16830754
16830778
213146_3p_at
213146_PM_at
213146_at
229452_PM_at
229452_at
23135
3709152
3709154
3709161
3709162
3709163
3709164
3709165
3709167
3709168
3709169
3709170
3709171
3709172
3709173
3709174
3709175
3709176
3709177
3709178
3709179
3709180
3709181
3709182
3709183
3709184
3709185
3709186
3709187
3709188
3709189
3709190
3709191
3709192
3709193
3709194
3709195
3709196
3709197
3709198
3709199
3709200
3709201
3709202
3709203
3709204
3709205
3709206
3709207
3709208
3709209
3709210
41386_3p_i_at
41386_PM_i_at
41386_i_at
41387_PM_r_at
41387_r_at
47544_at
4861272C_3p_s_at
8004671
8004691
A_23_P77859
A_24_P942630
GE53070
GE865339
GO:0000978
GO:0002376
GO:0002437
GO:0003677
GO:0003682
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006954
GO:0008013
GO:0010468
GO:0014823
GO:0016491
GO:0021766
GO:0030154
GO:0031490
GO:0032452
GO:0036211
GO:0043226
GO:0043565
GO:0044666
GO:0045165
GO:0045446
GO:0045944
GO:0046872
GO:0048333
GO:0048856
GO:0051213
GO:0055007
GO:0060992
GO:0070301
GO:0071558
GO:0120162
GO:0140096
HMNXSV003001169
HMNXSV003023385
HMNXSV003050941
Hs.103915.0.S1_3p_at
Hs.103915.0.S1_3p_s_at
Hs.103915.0.S1_3p_x_at
Hs.92955.0.A1_3p_at
Hs2.103915.2.A1_3p_s_at
ILMN_1757129
ILMN_2397521
PH_hs_0035516
PH_hs_0039865
TC17000117.hg
TC17000118.hg
Participates
as a member of
KDM6A,KDM6B,KDM6C,KDM7A [nucleoplasm] (Homo sapiens)
as an output of
AP-1 complex stimulates KDM6B transcription (Homo sapiens)
as an input of
KDM6B binds iron (Homo sapiens)
as a component of
KDM6B:Fe2+ [nucleoplasm] (Homo sapiens)
Inferred To
CYC8 [nucleoplasm]
(Saccharomyces cerevisiae)
Kdm6b [nucleoplasm]
(Rattus norvegicus)
Utx [nucleoplasm]
(Drosophila melanogaster)
utx-1 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of KDM6B [nucleoplasm]
(Caenorhabditis elegans)
jmjd-3.3 [nucleoplasm]
(Caenorhabditis elegans)
trfA [nucleoplasm]
(Dictyostelium discoideum)
jmjd-3.2 [nucleoplasm]
(Caenorhabditis elegans)
ssn6 [nucleoplasm]
(Schizosaccharomyces pombe)
kdm6b [nucleoplasm]
(Xenopus tropicalis)
KDM6B [nucleoplasm]
(Bos taurus)
KDM6B [nucleoplasm]
(Caenorhabditis elegans)
KDM6B [nucleoplasm]
(Canis familiaris)
KDM6B [nucleoplasm]
(Mus musculus)
KDM6B [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
XP_005256606.1
,
XP_011522054.1
,
XP_011522052.1
,
XP_005256608.1
,
NP_001335645.1
,
XP_006721546.1
,
NP_001073893.1
,
XP_005256607.1
,
XP_005256609.1
Guide to Pharmacology - Targets
2685
OpenTargets
ENSG00000132510
ZINC - Substances
KDM6B_HUMAN
ZINC target
O15054
PRO
O15054
PDB
4ASK
,
2XXZ
,
6F6D
,
5OY3
,
2XUE
,
5FP3
GeneCards
O15054
HPA
ENSG00000132510-KDM6B
Ensembl
ENSP00000254846
,
ENST00000448097
,
ENSP00000412513
,
ENST00000254846
,
ENSG00000132510
Pharos - Targets
O15054
Orphanet
29291
ZINC - Predictions - Purchasable
KDM6B_HUMAN
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