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CIT [cytosol]
Stable Identifier
R-HSA-1629806
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Citron Rho-interacting kinase, CRIK, Serine/threonine-protein kinase 21, KIAA0949, STK21
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate CIT (Homo sapiens)
Activated CIT binds KIF14 and PRC1 (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT [plasma membrane] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT:KIF14:PRC1 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT [plasma membrane] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
Activated CIT phosphorylates MRLCs (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT [plasma membrane] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT:CDKN1B [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT [plasma membrane] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT binds CDKN1B (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT:CDKN1B [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA binds effectors at the plasma membrane (Homo sapiens)
RHOA plasma membrane effectors [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RHOA:GTP:cytosolic RHOA effectors [plasma membrane] (Homo sapiens)
RHOA plasma membrane effectors [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB binds effectors at the plasma membrane (Homo sapiens)
RHOB effectors (plasma membrane) [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RHOB:GTP:cytosolic RHOB effectors [plasma membrane] (Homo sapiens)
RHOB effectors (plasma membrane) [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RHOC GTPase cycle (Homo sapiens)
RHOC binds effectors at the plasma membrane (Homo sapiens)
RHOC effectors [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RHOC:GTP:RHOC effectors [plasma membrane] (Homo sapiens)
RHOC effectors [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14578 CIT
Gene Names
CIT, CRIK, KIAA0949, STK21
Chain
chain:1-2027
Reference Genes
BioGPS Gene:11113 CIT
COSMIC (genes):CIT CIT
CTD Gene:11113 CIT
dbSNP Gene:11113 CIT
ENSEMBL:ENSG00000122966 CIT
HGNC:1985 CIT
KEGG:hsa:11113 CIT
Monarch:11113 CIT
NCBI Gene:11113 CIT
OMIM:605629 CIT
UCSC:O14578 CIT
Reference Transcript
RefSeq:NM_001206999.1 CIT
RefSeq:NM_007174.2 CIT
Participates
as a member of
RHOC effectors [cytosol] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
RHOB effectors (plasma membrane) [cytosol] (Homo sapiens)
as a component of
CIT [cytosol] (Homo sapiens)
Inferred To
CIT [cytosol]
(Bos taurus)
CIT [cytosol]
(Canis familiaris)
CIT [cytosol]
(Drosophila melanogaster)
CIT [cytosol]
(Gallus gallus)
CIT [cytosol]
(Mus musculus)
CIT [cytosol]
(Rattus norvegicus)
CIT [cytosol]
(Sus scrofa)
Cross References
Guide to Pharmacology - Targets
1509
ENSEMBL
ENSP00000376306
,
ENST00000392521
,
ENSG00000122966
,
ENST00000261833
,
ENSP00000261833
OpenTargets
ENSG00000122966
ZINC - FDA approved
CTRO_HUMAN
ZINC - Substances
CTRO_HUMAN
ZINC - Biogenic
CTRO_HUMAN
ZINC target
O14578
PRO
O14578
GlyGen
O14578
ZINC - Investigational
CTRO_HUMAN
GeneCards
CIT
HPA
ENSG00000122966-CIT
Pharos - Targets
O14578
Orphanet
CIT
ZINC - Predictions - Purchasable
CTRO_HUMAN
HMDB Protein
HMDBP01337
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