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CIT [cytosol]
Stable Identifier
R-HSA-1629806
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Citron Rho-interacting kinase, CRIK, Serine/threonine-protein kinase 21, KIAA0949, STK21
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate CIT (Homo sapiens)
Activated CIT binds KIF14 and PRC1 (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT [plasma membrane] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT:KIF14:PRC1 [plasma membrane] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT [plasma membrane] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
Activated CIT phosphorylates MRLCs (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT [plasma membrane] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT:CDKN1B [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RHOA,RHOB,RHOC,RAC1:GTP:CIT [plasma membrane] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT binds CDKN1B (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT:CDKN1B [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA binds effectors at the plasma membrane (Homo sapiens)
RHOA plasma membrane effectors [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RHOA:GTP:cytosolic RHOA effectors [plasma membrane] (Homo sapiens)
RHOA plasma membrane effectors [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB binds effectors at the plasma membrane (Homo sapiens)
RHOB effectors (plasma membrane) [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RHOB:GTP:cytosolic RHOB effectors [plasma membrane] (Homo sapiens)
RHOB effectors (plasma membrane) [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RHOC GTPase cycle (Homo sapiens)
RHOC binds effectors at the plasma membrane (Homo sapiens)
RHOC effectors [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
RHOC:GTP:RHOC effectors [plasma membrane] (Homo sapiens)
RHOC effectors [cytosol] (Homo sapiens)
CIT [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14578 CIT
Gene Names
CIT, CRIK, KIAA0949, STK21
Chain
chain:1-2027
Reference Genes
BioGPS Gene:11113 CIT
COSMIC (genes):CIT CIT
CTD Gene:11113 CIT
dbSNP Gene:11113 CIT
ENSEMBL:ENSG00000122966 CIT
ENSEMBL_homo_sapiens_GENE:ENSG00000122966.18 CIT
HGNC:1985 CIT
KEGG Gene (Homo sapiens):11113 CIT
Monarch:11113 CIT
NCBI Gene:11113 CIT
OMIM:605629 CIT
UCSC:O14578 CIT
Reference Transcript
RefSeq:NM_001206999.1 CIT
RefSeq:NM_007174.2 CIT
Other Identifiers
11113
11744436_a_at
11752591_a_at
16771067
212801_PM_at
212801_at
32081_at
3474107
3474108
3474109
3474110
3474111
3474112
3474115
3474116
3474117
3474118
3474119
3474121
3474122
3474123
3474125
3474126
3474133
3474134
3474135
3474137
3474138
3474139
3474140
3474141
3474142
3474143
3474144
3474145
3474147
3474148
3474149
3474150
3474152
3474153
3474154
3474155
3474156
3474158
3474160
3474161
3474162
3474164
3474165
3474168
3474170
3474171
3474177
3474181
3474187
3474188
3474189
3474190
3474192
3474193
3474194
3474195
3474197
3474199
7966878
A_23_P420551
A_33_P3312301
GE53620
GE86908
GO:0000166
GO:0000278
GO:0000281
GO:0000910
GO:0001223
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0006468
GO:0007049
GO:0007399
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0017124
GO:0019901
GO:0023052
GO:0030154
GO:0030165
GO:0030291
GO:0032467
GO:0035331
GO:0036211
GO:0046872
GO:0048699
GO:0048856
GO:0051301
GO:0051402
GO:0097110
GO:0098772
GO:0106310
GO:0110165
GO:0140096
HMNXSV003054159
Hs.15767.0.A1_3p_at
ILMN_1695579
PH_hs_0024665
TC12002032.hg
Participates
as a member of
RHOC effectors [cytosol] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
RHOB effectors (plasma membrane) [cytosol] (Homo sapiens)
as a component of
CIT [cytosol] (Homo sapiens)
Inferred To
CIT [cytosol]
(Bos taurus)
CIT [cytosol]
(Canis familiaris)
CIT [cytosol]
(Drosophila melanogaster)
CIT [cytosol]
(Gallus gallus)
CIT [cytosol]
(Mus musculus)
CIT [cytosol]
(Rattus norvegicus)
CIT [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001193928.1
,
NP_009105.1
ZINC - World Drugs
CTRO_HUMAN
Guide to Pharmacology - Targets
1509
OpenTargets
ENSG00000122966
ZINC - FDA approved
CTRO_HUMAN
ZINC - Substances
CTRO_HUMAN
ZINC target
O14578
ZINC - Biogenic
CTRO_HUMAN
PRO
O14578
ZINC - Investigational
CTRO_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000122966-CIT
GeneCards
O14578
Ensembl
ENST00000392521
,
ENSP00000261833
,
ENST00000261833
,
ENSP00000376306
,
ENSG00000122966
Pharos - Targets
O14578
ZINC - Predictions - Purchasable
CTRO_HUMAN
Orphanet
24009
© 2024
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