Reactome | N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate

N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate

Stable Identifier

R-HSA-162857

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate

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In the second step of GPI synthesis, N-acetylglucosaminyl-PI is hydrolyzed to yield glucosaminyl-PI and acetate. The phosphatidylinositol (PI) derivatives involved in this reaction are located in the endoplasmic reticulum membrane, as is the PIG-L enzyme that catalyzes it (Sharma et al. 1999; Pottekat and Menon 2004).

Literature References

PubMed ID	Title	Journal	Year
14742432	Subcellular localization and targeting of N-acetylglucosaminyl phosphatidylinositol de-N-acetylase, the second enzyme in the glycosylphosphatidylinositol biosynthetic pathway Pottekat, A, Menon, AK	J Biol Chem	2004
10089216	Differences between the trypanosomal and human GlcNAc-PI de-N-acetylases of glycosylphosphatidylinositol membrane anchor biosynthesis Sharma, DK, Smith, TK, Weller, CT, Crossman, A, Brimacombe, JS, Ferguson, MA	Glycobiology	1999