Reactome | N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate

N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate

Stable Identifier

R-HSA-162857

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In the second step of GPI synthesis, N-acetylglucosaminyl-PI is hydrolyzed to yield glucosaminyl-PI and acetate. The phosphatidylinositol (PI) derivatives involved in this reaction are located in the endoplasmic reticulum membrane, as is the PIG-L enzyme that catalyzes it (Sharma et al. 1999; Pottekat and Menon 2004).

Literature References

PubMed ID	Title	Journal	Year
14742432	Subcellular localization and targeting of N-acetylglucosaminyl phosphatidylinositol de-N-acetylase, the second enzyme in the glycosylphosphatidylinositol biosynthetic pathway Menon, AK, Pottekat, A	J Biol Chem	2004
10089216	Differences between the trypanosomal and human GlcNAc-PI de-N-acetylases of glycosylphosphatidylinositol membrane anchor biosynthesis Ferguson, MA, Brimacombe, JS, Smith, TK, Sharma, DK, Weller, CT, Crossman, A	Glycobiology	1999