Reorientation of glucosaminyl-acyl-PI in the endoplasmic reticulum membrane

Stable Identifier
R-HSA-162840
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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GPI moieties are synthesized anchored to dolichol phosphate in the membrane of the endoplasmic reticulum. The first two steps of the synthetic pathway, leading to the production of glucosaminyl-PI, occur on the cytosolic face of the membrane, while addition of an acyl group (step 4) and all subsequent steps occur on the lumenal face (Murakami et al. 2003). No mutant cell lines defective in the reorientation step have been identified, and the mechanism by which it occurs is unknown.

Literature References
PubMed ID Title Journal Year
11102867 Dissecting and manipulating the pathway for glycosylphosphatidylinositol-anchor biosynthesis

Kinoshita, T, Inoue, N

Curr Opin Chem Biol 2000
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