glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate

Stable Identifier
R-HSA-162830
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the fifth step of GPI synthesis, a mannose residue is added to glucosaminyl-acyl-PI. The reaction takes place at the lumenal surface of the endoplasmic reticulum membrane. It is catalyzed by a complex of at least two components, PIG-M and PIG-X (Maeda et al. 2001; Ashida et al. 2005).

Literature References
PubMed ID Title Journal Year
11226175 PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER

Maeda, Y, Watanabe, R, Harris, CL, Hong, Y, Ohishi, K, Kinoshita, K, Kinoshita, T

EMBO J 2001
15635094 Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I

Ashida, H, Hong, Y, Murakami, Y, Shishioh, N, Sugimoto, N, Kim, YU, Maeda, Y, Kinoshita, T

Mol Biol Cell 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
mannosyltransferase activity of GPI mannosyltransferase I [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
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