glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate

Stable Identifier
Reaction [transition]
Homo sapiens
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In the fifth step of GPI synthesis, a mannose residue is added to glucosaminyl-acyl-PI. The reaction takes place at the lumenal surface of the endoplasmic reticulum membrane. It is catalyzed by a complex of at least two components, PIG-M and PIG-X (Maeda et al. 2001; Ashida et al. 2005).

Literature References
PubMed ID Title Journal Year
15635094 Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I

Kinoshita, T, Murakami, Y, Kim, YU, Hong, Y, Ashida, H, Maeda, Y, Sugimoto, N, Shishioh, N

Mol Biol Cell 2005
11226175 PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER

Kinoshita, T, Watanabe, R, Ohishi, K, Hong, Y, Kinoshita, K, Harris, CL, Maeda, Y

EMBO J 2001
Catalyst Activity

mannosyltransferase activity of GPI mannosyltransferase I [endoplasmic reticulum membrane]

Orthologous Events
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