Reactome | glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate

glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate

Stable Identifier

R-HSA-162830

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

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glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate

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In the fifth step of GPI synthesis, a mannose residue is added to glucosaminyl-acyl-PI. The reaction takes place at the lumenal surface of the endoplasmic reticulum membrane. It is catalyzed by a complex of at least two components, PIG-M and PIG-X (Maeda et al. 2001; Ashida et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15635094	Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I Kinoshita, T, Murakami, Y, Kim, YU, Hong, Y, Ashida, H, Maeda, Y, Sugimoto, N, Shishioh, N	Mol Biol Cell	2005
11226175	PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER Kinoshita, T, Watanabe, R, Ohishi, K, Hong, Y, Kinoshita, K, Harris, CL, Maeda, Y	EMBO J	2001