mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol

Stable Identifier
Reaction [transition]
Homo sapiens
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In the sixth step of GPI synthesis, a phosphoethanolamine group is transferred from phosphatidylethanolamine onto the first mannose of the GPI precursor. The human protein that catalyzes this reaction was first identified because it could complement a yeast mutant strain defective for GPI synthesis (Gaynor et al. 1999); its specific function in phosphoethanolamine transfer is inferred from functional studies of the homologous mouse protein (Hong et al. 1999). The reaction is annotated here with phosphatidylethanolamine as the donor of the phosphoethanolamine group on the basis of studies in yeast (Imhof et al. 2000).

Literature References
PubMed ID Title Journal Year
10069808 MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast

Mondesert, G, Grimme, SJ, Emr, SD, Gaynor, EC, Orlean, P, Reed, SI

Mol Biol Cell 1999
Catalyst Activity

mannose-ethanolamine phosphotransferase activity of PIGN [endoplasmic reticulum membrane]

Orthologous Events
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