Reactome | PAK1 [cytosol]

PAK1 [cytosol]

Stable Identifier

R-HSA-162629

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p21-activated kinase

Icon

Locations in the PathwayBrowser for interactor UniProt:Q96EF9 ZHX1R

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G-protein beta:gamma signalling (Homo sapiens)
      - G beta:gamma signalling through CDC42 (Homo sapiens)
        
        PAK1 binds ARHGEF6 (Homo sapiens)
        
        PAK1 [cytosol] (Homo sapiens)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate PAKs (Homo sapiens)
        
        RAC1 and CDC42 activate PAK1 (Homo sapiens)
        
        PAK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13153 PAK1

Gene Names

PAK1

Chain

initiator methionine:, chain:2-545

Reference Genes

BioGPS Gene:5058 PAK1

COSMIC (genes):PAK1 PAK1

CTD Gene:5058 PAK1

dbSNP Gene:5058 PAK1

ENSEMBL:ENSG00000149269 PAK1

ENSEMBL_homo_sapiens_GENE:ENSG00000149269.10 PAK1

HGNC:8590 PAK1

KEGG Gene (Homo sapiens):5058 PAK1

Monarch:5058 PAK1

NCBI Gene:5058 PAK1

OMIM:602590 PAK1

UCSC:Q13153 PAK1

Reference Transcript

Other Identifiers

11720103_a_at

11720104_a_at

1557_at

1558_g_at

1565772_PM_at

1565772_at

16742454

209615_PM_s_at

209615_s_at

226507_PM_at

226507_at

230100_PM_x_at

230100_x_at

3382862

3382863

3382864

3382865

3382866

3382867

3382869

3382871

3382873

3382874

3382876

3382878

3382879

3382881

3382884

3382886

3382891

3382893

3382895

3382896

3382900

3382909

43052_at

43053_g_at

47835_at

5058

60859_at

7950578

A_23_P75989

A_33_P3288609

A_33_P3784253

GE59021

GE86276

GO:0000166

GO:0001726

GO:0001934

GO:0002223

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005518

GO:0005524

GO:0005634

GO:0005635

GO:0005654

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005911

GO:0005925

GO:0006325

GO:0006338

GO:0006468

GO:0006887

GO:0006915

GO:0006974

GO:0007010

GO:0008092

GO:0008152

GO:0008284

GO:0012501

GO:0014704

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0023052

GO:0030018

GO:0030027

GO:0030036

GO:0030154

GO:0030335

GO:0030424

GO:0030425

GO:0031116

GO:0031267

GO:0031965

GO:0032587

GO:0032956

GO:0032991

GO:0033138

GO:0033148

GO:0035556

GO:0036211

GO:0038096

GO:0042060

GO:0042802

GO:0042995

GO:0043015

GO:0043226

GO:0043408

GO:0043507

GO:0046777

GO:0048012

GO:0048013

GO:0048754

GO:0048812

GO:0048856

GO:0048870

GO:0050770

GO:0051179

GO:0051496

GO:0060244

GO:0065003

GO:0070161

GO:0090063

GO:0098542

GO:0106310

GO:0140096

GO:1903608

HMNXSV003022832

HMNXSV003030470

Hs.23295.0.A1_3p_at

Hs.329996.0.A1_3p_s_at

ILMN_1767365

PH_hs_0003990

TC11002123.hg

TC11003261.hg

U24152_at

g1256421_3p_a_at

p18341

Participates

as a member of

as an output of

as a candidate of

PAK [cytosol] (Homo sapiens)

as an input of

PAK1 binds ARHGEF6 (Homo sapiens)

as a component of

Other forms of this molecule

PAK1 [plasma membrane]

p-S144,T423-PAK1 [plasma membrane]

Active PAK1 [cytosol]

p-S144,T423-PAK1 [cytosol]

Inferred To

PAK1 [cytosol] (Bos taurus)

PAK1 [cytosol] (Caenorhabditis elegans)

PAK1 [cytosol] (Canis familiaris)

PAK1 [cytosol] (Dictyostelium discoideum)

PAK1 [cytosol] (Drosophila melanogaster)

PAK1 [cytosol] (Gallus gallus)

PAK1 [cytosol] (Mus musculus)

PAK1 [cytosol] (Rattus norvegicus)

PAK1 [cytosol] (Saccharomyces cerevisiae)

PAK1 [cytosol] (Schizosaccharomyces pombe)

PAK1 [cytosol] (Sus scrofa)

PAK1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_011543386.1, XP_016873335.1, XP_016873337.1, NP_001122092.1, XP_011543383.1, XP_016873339.1, XP_011543385.1, NP_002567.3, XP_016873336.1, XP_011543382.1, XP_016873338.1, XP_011543384.1

ZINC - World Drugs

PAK1_HUMAN

Guide to Pharmacology - Targets

2133

OpenTargets

ENSG00000149269

ZINC - FDA approved

PAK1_HUMAN

ZINC - Substances

PAK1_HUMAN

ZINC - Biogenic

PAK1_HUMAN

ZINC target

Q13153

PRO

Q13153

PDB

3DVP, 2QME, 4O0R, 4ZJI, 4P90, 4ZJJ, 1YHW, 5IME, 6B16, 3FY0, 5DEW, 4EQC, 5KBQ, 8X5Z, 1YHV, 5DEY, 7VTO, 5KBR, 4O0T, 3FXZ, 4ZLO, 4DAW, 2HY8, 4ZY5, 4ZY6, 3Q52, 3Q4Z, 1ZSG, 3Q53, 5DFP, 4ZY4, 1F3M

ZINC - Investigational

PAK1_HUMAN

GeneCards

Q13153

HPA

ENSG00000149269-PAK1

Ensembl

ENSP00000348696, ENSG00000149269, ENST00000356341, ENSP00000278568, ENST00000278568

Pharos - Targets

Q13153

ZINC - Predictions - Purchasable

PAK1_HUMAN

HMDB Protein

HMDBP08499

Interactors (54)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.977	28
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.953	16
UniProt:P60953 CDC42	3	CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545)	0.944	15
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.939	13
UniProt:Q15052 ARHGEF6	1	ARHGEF6 [cytosol] (R-HSA-195017)	0.798	7
GTP [ChEBI:15996]	7	GTP [cilium] (R-ALL-5617813) GTP [early endosome membrane] (R-ALL-2130170) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221)	0.778	4
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.744	5
UniProt:P21127 CDK11B	1	CDK11B [cytosol] (R-HSA-380451)	0.69	4
UniProt:P63001 Rac1	7	RAC1 [ficolin-1-rich granule membrane] (R-MMU-6804802) RAC1 [secretory granule membrane] (R-MMU-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-MMU-2316446) RAC1 [endoplasmic reticulum membrane] (R-MMU-5672076) Rac1 [plasma membrane] (R-MMU-2316449) RAC1 [cytosol] (R-MMU-442615) Rac1 [plasma membrane] (R-MMU-421093)	0.688	3
UniProt:P60766 Cdc42	3	CDC42 [endoplasmic reticulum membrane] (R-MMU-5672086) CDC42 [cytosol] (R-MMU-442630) Cdc42 [plasma membrane] (R-MMU-448841)	0.688	3
UniProt:Q14161 GIT2	1	GIT2 [cytosol] (R-HSA-446034)	0.669	4
UniProt:Q9H4E5 RHOJ	1	RHOJ [plasma membrane] (R-HSA-3006725)	0.666	4
UniProt:P63167 DYNLL1	6	DYNLL1 [ciliary tip] (R-HSA-5625335) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [cytosol] (R-HSA-387105)	0.666	4
UniProt:B3KX85 B3KX85			0.645	6
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653)	0.643	4
UniProt:P63000-1 RAC1			0.641	3
UniProt:Q92963 RIT1	1	RIT1 [plasma membrane] (R-HSA-187703)	0.619	4
UniProt:P53667 LIMK1	3	p-S,T508-LIMK1 [cytosol] (R-HSA-419610) p-T508-LIMK1 [cytosol] (R-HSA-399816) LIMK1 [cytosol] (R-HSA-397785)	0.619	5
UniProt:P62999	6	RAC1 [ficolin-1-rich granule membrane] (R-CFA-6804802-2) RAC1 [secretory granule membrane] (R-CFA-6804770-2) GGC-PalmC-RAC1 [plasma membrane] (R-CFA-2316446-2) RAC1 [endoplasmic reticulum membrane] (R-CFA-5672076-2) RAC1 [cytosol] (R-CFA-442615-2) RAC1 [plasma membrane] (R-CFA-351141-2)	0.617	3
UniProt:Q7L0Q8 RHOU	4	p-Y254-RHOU [endosome membrane] (R-HSA-9726860) p-Y254-RHOU [plasma membrane] (R-HSA-9726857) RHOU [plasma membrane] (R-HSA-194914) RHOU [cytosol] (R-HSA-194901)	0.589	3
UniProt:Q5PP90 Q5PP90			0.558	2
UniProt:Q96EF9 ZHX1R			0.556	3
UniProt:Q96BD6 SPSB1	1	SPSB1 [cytosol] (R-HSA-976024)	0.556	3
UniProt:Q9H892-2 TTC12			0.556	3
IntAct:EBI-25839738 CCSB			0.556	3
UniProt:P11117 PPAL			0.556	3
UniProt:Q9BXU0 TEX12	1	TEX12 [nucleoplasm] (R-HSA-912441)	0.556	3
UniProt:O15273 TCAP	1	TCAP [cytosol] (R-HSA-390571)	0.556	3
UniProt:Q9Y2M5 KLHL20	1	KLHL20 [cytosol] (R-HSA-976032)	0.556	3
UniProt:Q15759 MAPK11	4	p-T180,Y182-MAPK11 [nucleoplasm] (R-HSA-198741) MAPK11 [nucleoplasm] (R-HSA-203790) MAPK11 [cytosol] (R-HSA-170989) p-T180,Y182-MAPK11 [cytosol] (R-HSA-171009)	0.556	3
UniProt:O60830 TIMM17B	2	TIMM17B [mitochondrial intermembrane space] (R-HSA-1955371) TIMM17B [mitochondrial inner membrane] (R-HSA-1252138)	0.556	3
UniProt:P32243-2 OTX2			0.556	3
UniProt:Q8WZ73-3 Q8WZ733			0.556	3
UniProt:Q9NTN9-3 SEMA4G			0.556	3
IntAct:EBI-25839688 CCSB			0.556	3
UniProt:Q8N0Y2-2 ZNF444			0.556	3
UniProt:Q6NZ36-4 FAAP20			0.556	3
UniProt:Q9H0W9-3 C11ORF54			0.556	3
UniProt:O75558 STX11			0.556	3
UniProt:Q14847-2 LASP1			0.556	3
IntAct:EBI-25835277 CCSB			0.556	3
UniProt:Q8TDR4 TCP1L			0.556	3
UniProt:Q96A04 TSACC			0.556	3
UniProt:O60506-4 SYNCRIP			0.556	3
UniProt:Q13322-4 GRB10			0.556	3
UniProt:Q8N490-3 PNKD			0.556	3
UniProt:P35611 ADD1	3	ADD1(634-737) [cytosol] (R-HSA-202890) ADD1(1-633) [cytosol] (R-HSA-202891) ADD1 [cytosol] (R-HSA-201623)	0.556	3
UniProt:Q9Y239 NOD1	1	NOD1 [cytosol] (R-HSA-168407)	0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P60953-2 CDC42			0.547	2
UniProt:Q9NVF7 FBX28			0.527	4
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.527	3
UniProt:Q15365 PCBP1	1	PCBP1 [nucleoplasm] (R-HSA-71919)	0.524	2
UniProt:Q05513-1 PRKCZ			0.499	5

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