PDE3B hydrolyzes cAMP to AMP downstream of insulin signaling to regulate energy homeostasis (Marganiello et al, 1995; Degerman et al, 1997; Degerman et al, 2011; DiPilato et al, 2015).
DiPilato, LM, Harms, M, Birnbaum, MJ, Seale, P, Manganiello, V, Ahmad, F
Degerman, E, Manganiello, VC, Belfrage, P, Taira, M
Degerman, E, Manganiello, VC, Belfrage, P
Guirguis, E, Manganiello, V, Chung, YW, Degerman, E, Ahmad, F, Stenson, L, Omar, B
3',5'-cyclic-nucleotide phosphodiesterase activity of p-S295-PDE3B [cytosol]
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