Reactome | p-S295-PDE3B hydrolyses cAMP to AMP

p-S295-PDE3B hydrolyses cAMP to AMP

Stable Identifier

R-HSA-162425

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor signalling cascade (Homo sapiens)
      - IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        PKB-mediated events (Homo sapiens)
        
        PDE3B signalling (Homo sapiens)
        
        p-S295-PDE3B hydrolyses cAMP to AMP (Homo sapiens)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
    - IGF1R signaling cascade (Homo sapiens)
      - IRS-related events triggered by IGF1R (Homo sapiens)
        
        IRS-mediated signalling (Homo sapiens)
        
        PI3K Cascade (Homo sapiens)
        
        PKB-mediated events (Homo sapiens)
        
        PDE3B signalling (Homo sapiens)
        
        p-S295-PDE3B hydrolyses cAMP to AMP (Homo sapiens)

General

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PDE3B hydrolyzes cAMP to AMP downstream of insulin signaling to regulate energy homeostasis (Marganiello et al, 1995; Degerman et al, 1997; Degerman et al, 2011; DiPilato et al, 2015).

Literature References

PubMed ID	Title	Journal	Year
26031333	The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin DiPilato, LM, Harms, M, Birnbaum, MJ, Seale, P, Manganiello, V, Ahmad, F	Mol. Cell. Biol.	2015
8562305	Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family) Degerman, E, Manganiello, VC, Belfrage, P, Taira, M	Cell Signal	1995
9102399	Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3) Degerman, E, Manganiello, VC, Belfrage, P	J Biol Chem	1997
22001403	From PDE3B to the regulation of energy homeostasis Guirguis, E, Manganiello, V, Chung, YW, Degerman, E, Ahmad, F, Stenson, L, Omar, B	Curr Opin Pharmacol	2011