p-S295-PDE3B hydrolyses cAMP to AMP

Stable Identifier
R-HSA-162425
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PDE3B hydrolyzes cAMP to AMP downstream of insulin signaling to regulate energy homeostasis (Marganiello et al, 1995; Degerman et al, 1997; Degerman et al, 2011; DiPilato et al, 2015).

Literature References
PubMed ID Title Journal Year
8562305 Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family)

Manganiello, VC, Taira, M, Degerman, E, Belfrage, P

Cell Signal 1995
26031333 The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin

DiPilato, LM, Ahmad, F, Harms, M, Seale, P, Manganiello, V, Birnbaum, MJ

Mol. Cell. Biol. 2015
9102399 Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3)

Degerman, E, Belfrage, P, Manganiello, VC

J Biol Chem 1997
22001403 From PDE3B to the regulation of energy homeostasis

Degerman, E, Ahmad, F, Chung, YW, Guirguis, E, Omar, B, Stenson, L, Manganiello, V

Curr Opin Pharmacol 2011
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
3',5'-cyclic-nucleotide phosphodiesterase activity of p-S295-PDE3B [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Created