p-S295-PDE3B hydrolyses cAMP to AMP

Stable Identifier
R-HSA-162425
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PDE3B hydrolyzes cAMP to AMP downstream of insulin signaling to regulate energy homeostasis (Marganiello et al, 1995; Degerman et al, 1997; Degerman et al, 2011; DiPilato et al, 2015).

Literature References
PubMed ID Title Journal Year
26031333 The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin

DiPilato, LM, Harms, M, Birnbaum, MJ, Seale, P, Manganiello, V, Ahmad, F

Mol. Cell. Biol. 2015
8562305 Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family)

Degerman, E, Manganiello, VC, Belfrage, P, Taira, M

Cell Signal 1995
9102399 Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3)

Degerman, E, Manganiello, VC, Belfrage, P

J Biol Chem 1997
22001403 From PDE3B to the regulation of energy homeostasis

Guirguis, E, Manganiello, V, Chung, YW, Degerman, E, Ahmad, F, Stenson, L, Omar, B

Curr Opin Pharmacol 2011
Participants
Output
Participates
Catalyst Activity

3',5'-cyclic-nucleotide phosphodiesterase activity of p-S295-PDE3B [cytosol]

Orthologous Events
Cross References
Rhea
Created
Cite Us!