Homocysteine is degraded to oxobutanoate and H2S

Stable Identifier
R-HSA-1614631
Type
Reaction
Species
Homo sapiens
Compartment
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Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoate, lanthionine, and homolanthionine are produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)

Literature References
PubMed ID Title Journal Year
10212249 Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration

Marinkovic, S, Huber, R, Steegborn, C, Sondermann, P, Wahl, MC, Clausen, T, Worbs, M, Jacob, U

J Biol Chem 1999
19261609 H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia

Zhu, W, Chiku, T, Padovani, D, Banerjee, R, Singh, S, Vitvitsky, V

J Biol Chem 2009
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Catalyst Activity

homocysteine desulfhydrase activity of PXLP-K212-CTH tetramer [cytosol]

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