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PXLP-K212-CTH [cytosol]
Stable Identifier
R-HSA-1614606
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Cystathionine gamma-lyase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Selenoamino acid metabolism (Homo sapiens)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Homo sapiens)
Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH (Homo sapiens)
PXLP-K212-CTH tetramer [cytosol] (Homo sapiens)
PXLP-K212-CTH [cytosol] (Homo sapiens)
MeSec is hydrolysed to MeSeH by PXLP-K212-CTH (Homo sapiens)
PXLP-K212-CTH tetramer [cytosol] (Homo sapiens)
PXLP-K212-CTH [cytosol] (Homo sapiens)
SeCysta is hydrolysed to Sec by PXLP-K212-CTH (Homo sapiens)
PXLP-K212-CTH tetramer [cytosol] (Homo sapiens)
PXLP-K212-CTH [cytosol] (Homo sapiens)
Sulfur amino acid metabolism (Homo sapiens)
Cysteine formation from homocysteine (Homo sapiens)
PXLP-K212-CTH cleaves L-Cystathionine (Homo sapiens)
PXLP-K212-CTH tetramer [cytosol] (Homo sapiens)
PXLP-K212-CTH [cytosol] (Homo sapiens)
Degradation of cysteine and homocysteine (Homo sapiens)
Cysteine is degraded to serine and H2S (Homo sapiens)
PXLP-K212-CTH tetramer [cytosol] (Homo sapiens)
PXLP-K212-CTH [cytosol] (Homo sapiens)
Excess cysteine yields lanthionine and H2S (Homo sapiens)
PXLP-K212-CTH tetramer [cytosol] (Homo sapiens)
PXLP-K212-CTH [cytosol] (Homo sapiens)
Excess homocysteine yields homolanthionine and H2S (Homo sapiens)
PXLP-K212-CTH tetramer [cytosol] (Homo sapiens)
PXLP-K212-CTH [cytosol] (Homo sapiens)
Homocysteine is degraded to oxobutanoate and H2S (Homo sapiens)
PXLP-K212-CTH tetramer [cytosol] (Homo sapiens)
PXLP-K212-CTH [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P32929 CTH
Gene Names
CTH
Chain
chain:1-405
Reference Genes
BioGPS Gene:1491 CTH
COSMIC (genes):CTH CTH
CTD Gene:1491 CTH
dbSNP Gene:1491 CTH
ENSEMBL:ENSG00000116761 CTH
HGNC:2501 CTH
KEGG:hsa:1491 CTH
Monarch:1491 CTH
NCBI Gene:1491 CTH
OMIM:607657 CTH
UCSC:P32929 CTH
Reference Transcript
RefSeq:NM_153742.4 CTH
RefSeq:NM_001902.5 CTH
RefSeq:NM_001190463.1 CTH
Other Identifiers
11742278_a_at
1491
16666055
206085_PM_s_at
206085_s_at
217127_PM_at
217127_at
2341667
2341668
2341669
2341670
2341674
2341675
2341676
2341678
2341679
2341680
2341681
2341682
2341683
2341684
2341685
2341686
2341687
2341688
32962_at
77777_at
7902290
A_14_P107890
A_23_P126103
GE58780
GO:0003824
GO:0004123
GO:0005515
GO:0005516
GO:0005737
GO:0005829
GO:0006520
GO:0006534
GO:0006629
GO:0006790
GO:0016829
GO:0018272
GO:0019343
GO:0019344
GO:0019346
GO:0030170
GO:0030968
GO:0042802
GO:0043066
GO:0043123
GO:0043226
GO:0044524
GO:0044540
GO:0047982
GO:0051289
GO:0065003
GO:0070062
GO:0070814
GO:0080146
GO:0098606
GO:1904831
GO:1990830
GO:2001234
HMNXSV003002528
ILMN_1777060
ILMN_2305112
ILMN_2305116
PH_hs_0001733
S52028_s_at
TC01000757.hg
g4503124_3p_a_at
Participates
as a component of
PXLP-K212-CTH tetramer [cytosol] (Homo sapiens)
Inferred To
CTH [cytosol]
(Canis familiaris)
CTH [cytosol]
(Gallus gallus)
cthl [cytosol]
(Danio rerio)
PXLP-K212-CTH [cytosol]
(Bos taurus)
PXLP-K212-CTH [cytosol]
(Caenorhabditis elegans)
PXLP-K212-CTH [cytosol]
(Dictyostelium discoideum)
PXLP-K212-CTH [cytosol]
(Mus musculus)
PXLP-K212-CTH [cytosol]
(Rattus norvegicus)
PXLP-K212-CTH [cytosol]
(Saccharomyces cerevisiae)
PXLP-K212-CTH [cytosol]
(Schizosaccharomyces pombe)
PXLP-K212-CTH [cytosol]
(Sus scrofa)
Cth [cytosol]
(Drosophila melanogaster)
cth [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
N6-pyridoxal phosphate-L-lysine at 212
Coordinate
212
PsiMod Name
N6-pyridoxal phosphate-L-lysine [MOD:00128]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.
Cross References
Guide to Pharmacology - Targets
1444
ENSEMBL
ENST00000370938
,
ENST00000411986
,
ENSP00000311554
,
ENST00000346806
,
ENSP00000413407
,
ENSP00000359976
OpenTargets
ENSG00000116761
IntEnz
4.4.1.1
HPA
ENSG00000116761-CTH
PRO
P32929
Pharos - Targets
P32929
GlyGen
P32929
Orphanet
CTH
HMDB Protein
HMDBP00538
PDB
2NMP
,
5EIG
,
6NBA
,
5TT2
,
6OVG
,
3ELP
,
5TSU
,
3COG
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