Reactome | Cysteine formation from homocysteine

Cysteine formation from homocysteine

Stable Identifier

R-HSA-1614603

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Transsulfuration is the interconversion of homocysteine and cysteine, and it fully takes place in bacteria and some plants and fungi. Animals however have only one direction of this bidirectional path, the synthesis of cysteine from homocysteine via cystathionine. Because excess cysteine is degraded to hydrogen sulfide, which is now known as a neuromodulator and smooth muscle relaxant, this pathway is also the main source of its production, which takes place in the cytosol, as well as in extracellular space (Dominy & Stipanuk 2004, Bearden et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20817827	Extracellular transsulfuration generates hydrogen sulfide from homocysteine and protects endothelium from redox stress Beard RS, Jr, Bearden, SE, Pfau, JC	Am J Physiol Heart Circ Physiol	2010
15497768	New roles for cysteine and transsulfuration enzymes: production of H2S, a neuromodulator and smooth muscle relaxant Dominy, JE, Stipanuk, MH	Nutr Rev	2004