Reactome | Excess cysteine yields lanthionine and H2S

Excess cysteine yields lanthionine and H2S

Stable Identifier

R-HSA-1614591

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

2 L-cysteine => H(+) + hydrogen sulfide + L-lanthionine

ReviewStatus

5/5

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Excess cysteine yields lanthionine and H2S

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Excess cysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In this reactions, lanthionine is produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)

Literature References

PubMed ID	Title	Journal	Year
10212249	Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration Steegborn, C, Clausen, T, Sondermann, P, Jacob, U, Worbs, M, Marinkovic, S, Huber, R, Wahl, MC	J Biol Chem	1999
19261609	H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia Chiku, T, Padovani, D, Zhu, W, Singh, S, Vitvitsky, V, Banerjee, R	J Biol Chem	2009