Excess cysteine yields lanthionine and H2S

Stable Identifier
R-HSA-1614591
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Excess cysteine yields lanthionine and H2S
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Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoate, lanthionine, and homolanthionine are produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)

Literature References
PubMed ID Title Journal Year
19261609 H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia

Chiku, T, Padovani, D, Zhu, W, Singh, S, Vitvitsky, V, Banerjee, R

J Biol Chem 2009
10212249 Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration

Steegborn, C, Clausen, T, Sondermann, P, Jacob, U, Worbs, M, Marinkovic, S, Huber, R, Wahl, MC

J Biol Chem 1999
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
L-cysteine desulfhydrase activity of PXLP-K212-CTH tetramer [cytosol]
Physical Entity
PXLP-K212-CTH tetramer [cytosol]
Activity
L-cysteine desulfhydrase activity (0080146)
This event is regulated
Positively by
Orthologous Events
Excess cysteine yields lanthionine and H2S (Bos taurus)
Excess cysteine yields lanthionine and H2S (Caenorhabditis elegans)
Excess cysteine yields lanthionine and H2S (Canis familiaris)
Excess cysteine yields lanthionine and H2S (Danio rerio)
Excess cysteine yields lanthionine and H2S (Dictyostelium discoideum)
Excess cysteine yields lanthionine and H2S (Drosophila melanogaster)
Excess cysteine yields lanthionine and H2S (Gallus gallus)
Excess cysteine yields lanthionine and H2S (Mus musculus)
Excess cysteine yields lanthionine and H2S (Rattus norvegicus)
Excess cysteine yields lanthionine and H2S (Saccharomyces cerevisiae)
Excess cysteine yields lanthionine and H2S (Schizosaccharomyces pombe)
Excess cysteine yields lanthionine and H2S (Xenopus tropicalis)
Authored
Stephan, R  (2010-10-24)
Reviewed
D'Eustachio, P  (2011-10-13)
Created
Jassal, B  (2011-09-29)
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