Excess cysteine yields lanthionine and H2S

Stable Identifier
R-HSA-1614591
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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Excess cysteine yields lanthionine and H2S
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Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoate, lanthionine, and homolanthionine are produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)

Literature References
PubMed ID Title Journal Year
10212249 Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration

Marinkovic, S, Huber, R, Steegborn, C, Sondermann, P, Wahl, MC, Clausen, T, Worbs, M, Jacob, U

J Biol Chem 1999
19261609 H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia

Zhu, W, Chiku, T, Padovani, D, Banerjee, R, Singh, S, Vitvitsky, V

J Biol Chem 2009
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Input
Output
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as an event of
Catalyst Activity

L-cysteine desulfhydrase activity of PXLP-K212-CTH tetramer [cytosol]

Physical Entity
PXLP-K212-CTH tetramer [cytosol] (Homo sapiens)
Activity
L-cysteine desulfhydrase activity (GO:0080146)
This event is regulated
Positively by
Regulator
L-Cys [cytosol]
Orthologous Events
Excess cysteine yields lanthionine and H2S (Bos taurus)
Excess cysteine yields lanthionine and H2S (Caenorhabditis elegans)
Excess cysteine yields lanthionine and H2S (Canis familiaris)
Excess cysteine yields lanthionine and H2S (Danio rerio)
Excess cysteine yields lanthionine and H2S (Dictyostelium discoideum)
Excess cysteine yields lanthionine and H2S (Drosophila melanogaster)
Excess cysteine yields lanthionine and H2S (Gallus gallus)
Excess cysteine yields lanthionine and H2S (Mus musculus)
Excess cysteine yields lanthionine and H2S (Rattus norvegicus)
Excess cysteine yields lanthionine and H2S (Saccharomyces cerevisiae)
Excess cysteine yields lanthionine and H2S (Schizosaccharomyces pombe)
Excess cysteine yields lanthionine and H2S (Xenopus tropicalis)
Cross References
Rhea
Authored
Stephan, R  (2010-10-24)
Reviewed
D'Eustachio, P  (2011-10-13)
Created
Jassal, B  (2011-09-29)
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