Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoate, lanthionine, and homolanthionine are produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)
Chiku, T, Padovani, D, Zhu, W, Singh, S, Vitvitsky, V, Banerjee, R
Steegborn, C, Clausen, T, Sondermann, P, Jacob, U, Worbs, M, Marinkovic, S, Huber, R, Wahl, MC
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