PXLP-K212-CTH cleaves L-Cystathionine

Stable Identifier
R-HSA-1614583
Type
Reaction
Species
Homo sapiens
Compartment
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Cystathionine is cleaved to cysteine, oxobutanoate, and ammonia by the alpha,gamma-elimination activity of cystathionine gamma-lyase (CTH). CTH utilises pyridoxal 5'-phosphate (PXLP) as cofactor (Chiku et al. 2009, Steegborn et al. 1999).

Literature References
PubMed ID Title Journal Year
10212249 Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration

Marinkovic, S, Huber, R, Steegborn, C, Sondermann, P, Wahl, MC, Clausen, T, Worbs, M, Jacob, U

J Biol Chem 1999
19261609 H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia

Zhu, W, Chiku, T, Padovani, D, Banerjee, R, Singh, S, Vitvitsky, V

J Biol Chem 2009
Participants
Participates
Catalyst Activity

cystathionine gamma-lyase activity of PXLP-K212-CTH tetramer [cytosol]

Orthologous Events
Cross References
Rhea
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