Sulfide oxidation to sulfate

Stable Identifier
R-HSA-1614517
Type
Pathway
Species
Homo sapiens
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While the human body is very economical with sulfur amino acids (SAA), superfluous SAA are degraded via cysteine to toxic hydrogen sulfide which must be dealt with. The pathway to oxidize this gas is localized to mitochondria and is highly conserved, pointing back to a time when life was immersed in sulfide-rich waters.
The pathway for sulfide oxidation consists of five reactions, one of which, the sulfur transfer from thiosulfate to glutathione, is still to be characterized fully. A mutation in one enzyme has been identified that is associated with ethylmalonyl encephalopathy and where tissue sulfide is elevated (Stipanuk & Ueki 2011).

Literature References
PubMed ID Title Journal Year
20162368 Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur

Stipanuk, MH, Ueki, I

J Inherit Metab Dis 2011
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