ARSC hydrolyzes steroid sulfates

Stable Identifier
Reaction [transition]
Homo sapiens
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Steryl sulfatase (formerly arylsulfatase C, ARSC) hydrolyses sulfate from steroid sulfates (Noel et al. 1983, Vaccaro et al. 1987, Suzuki et al. 1992). It is located on the ER membrane (Stein et al. 1989) and functions as a homodimer, using calcium as a cofactor. Defects in STS are the cause of ichthyosis X-linked (IXL) (MIM:308100), a keratinisation disorder (Basler et al. 1992, Alperin & Shapiro 1997).
Literature References
PubMed ID Title Journal Year
1539590 Identification of point mutations in the steroid sulfatase gene of three patients with X-linked ichthyosis

Basler, E, Ballabio, A, Grompe, M, Parenti, G, Yates, J

Am J Hum Genet 1992
2953589 Purification and properties of arylsulfatase C from human placenta

Muscillo, M, Renola, L, Salvioli, R, Vaccaro, AM

Enzyme 1987
2668275 Cloning and expression of human steroid-sulfatase. Membrane topology, glycosylation, and subcellular distribution in BHK-21 cells

Stein, C, Rijnbout, S, Seidel, J, Hille, A, von Figura, K, Geuze, H, Waheed, A, Schmidt, B

J Biol Chem 1989
6417417 Human placental steroid sulfatase: purification and properties

Bleau, G, Roberts, KD, Plante, L, Noël, H, Chapdelaine, A

J Steroid Biochem 1983
1606923 Purification and properties of steroid sulfatase from human placenta

Yanaihara, N, Yanaihara, T, Sato, T, Hirato, K, Hoshino, M, Suzuki, T, Kadofuku, T

Endocrinol Jpn 1992
9252398 Characterization of point mutations in patients with X-linked ichthyosis. Effects on the structure and function of the steroid sulfatase protein

Alperin, ES, Shapiro, LJ

J Biol Chem 1997
Catalyst Activity

steryl-sulfatase activity of active STS dimer [endoplasmic reticulum membrane]

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