Reactome | ASAH2 hydrolyzes ceramide (plasma membrane)

ASAH2 hydrolyzes ceramide (plasma membrane)

Stable Identifier

R-HSA-1606583

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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ASAH2 hydrolyzes ceramide (plasma membrane)

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Neutral ceramidase (ASAH2) is an enzyme localised to the plasma membrane that catalyses the hydrolysis of ceramide to sphingosine and free fatty acid (Hwang et al. 2005, Galadari et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16229686	Identification of a novel amidase motif in neutral ceramidase Mao, C, Roddy, P, Hannun, YA, Wu, BX, Galadari, S, El Bawab, S	Biochem J	2006
15845354	Subcellular localization of human neutral ceramidase expressed in HEK293 cells Okino, N, Nakagawa, T, Ito, M, Tani, M, Hwang, YH	Biochem Biophys Res Commun	2005