Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)

Stable Identifier
R-HSA-1606583
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Neutral ceramidase (ASAH2) is an enzyme localised to the plasma membrane that catalyses the hydrolysis of ceramide to sphingosine and free fatty acid (Hwang et al. 2005, Galadari et al. 2006).

Literature References
PubMed ID Title Journal Year
15845354 Subcellular localization of human neutral ceramidase expressed in HEK293 cells

Hwang, YH, Tani, M, Nakagawa, T, Okino, N, Ito, M

Biochem Biophys Res Commun 2005
16229686 Identification of a novel amidase motif in neutral ceramidase

Galadari, S, Wu, BX, Mao, C, Roddy, P, El Bawab, S, Hannun, YA

Biochem J 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
N-acylsphingosine amidohydrolase activity of ASAH2-like proteins [plasma membrane]
Physical Entity
Activity
Orthologous Events
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