MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA

Stable Identifier
R-HSA-1606561
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA
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Translation of NOTCH1 mRNA is negatively regulated by MIR449 microRNAs (MIR449A, MIR449B and MIR449C), which bind to the 3'UTR of NOTCH1. Downregulation of NOTCH1 signaling by the MIR449 cluster appears to be an evolutionarily conserved mechanism involved in regulation of vertebrate multiciliogenesis. DLL1 mRNA is also a target of the MIR449 cluster.

Literature References
PubMed ID Title Journal Year
21602795 Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway

Moreilhon, C, Coraux, C, Robbe-Sermesant, K, Kodjabachian, L, Barbry, P, Waldmann, R, Cardinaud, B, Chevalier, B, Marcet, B, Zaragosi, LE, Jolly, T, Birembaut, P, Nawrocki-Raby, B, Cibois, M, Luxardi, G, Giovannini-Chami, L

Nat Cell Biol 2011
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Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-09-22)
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