Recruitment of IRF3 to activated ZBP1:TBK1

Stable Identifier
R-HSA-1606345
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human alphaherpesvirus 2, Human cytomegalovirus
Compartment
cytosol
ReviewStatus
5/5
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Recruitment of IRF3 to activated ZBP1:TBK1
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ZBP1 (DAI) dimer formation enables recruitment of TBK1 and IRF3 to the C-terminal region of DAI in response to cytosolic DNA in murine L929 cells. This interaction is DNA-dependent as ZBP1(DAI) mutants that lack DNA binding domains neither recruited TBK1 nor activated IRF3 (Takaoka A et al 2007). Activation of IRF-3 and possibly IRF-7 promotes IFN gene expression.

Literature References
PubMed ID Title Journal Year
17618271 DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

Lu, Y, Choi, MK, Ohba, Y, Ban, T, Miyagishi, M, Yanai, H, Honda, K, Wang, Z, Takaoka, A, Taniguchi, T, Kodama, T, Negishi, H

Nature 2007
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
TBK1:amlexanox [cytosol] (Homo sapiens)
Inferred From
Recruitment of Irf3 to activated Dai:Tbk1 (Mus musculus)
Authored
Shamovsky, V  (2011-09-21)
Reviewed
Mocarski, ES  (2012-02-19)
Upton, JW  (2012-02-19)
D'Eustachio, P  (2011-12-08)
Created
Shamovsky, V  (2011-09-21)
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