Reactome | SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)

SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)

Stable Identifier

R-HSA-1606273

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)

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The mammalian brain-specific, Mg2+-dependent, neutral sphingomyelin phosphodiesterases 2 (Tomiuk et al. 1998, Hofmann et al. 2000) and 3 (Marchesini et al. 2003) (SMPD2 and 3) hydrolyse sphingomyelin (SPHM) to ceramide (CERA) at the plasma membrane.

Literature References

PubMed ID	Title	Journal	Year
9520418	Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling? Tomiuk, S, Hofmann, K, Nix, M, Zumbansen, M, Stoffel, W	Proc Natl Acad Sci U S A	1998
10823942	Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase Hofmann, K, Tomiuk, S, Wolff, G, Stoffel, W	Proc Natl Acad Sci U S A	2000
12566438	Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism Marchesini, N, Luberto, C, Hannun, YA	J Biol Chem	2003