Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)

Stable Identifier
R-HSA-1606273
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The mammalian brain-specific, Mg2+-dependent, neutral sphingomyelin phosphodiesterases 2 (Tomiuk et al. 1998, Hofmann et al. 2000) and 3 (Marchesini et al. 2003) (SMPD2 and 3) hydrolyse sphingomyelin (SPHM) to ceramide (CERA) at the plasma membrane.

Literature References
PubMed ID Title Journal Year
10823942 Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase

Hofmann, K, Tomiuk, S, Wolff, G, Stoffel, W

Proc Natl Acad Sci U S A 2000
9520418 Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?

Tomiuk, S, Hofmann, K, Nix, M, Zumbansen, M, Stoffel, W

Proc Natl Acad Sci U S A 1998
12566438 Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism

Marchesini, N, Luberto, C, Hannun, YA

J Biol Chem 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
sphingomyelin phosphodiesterase activity of SMPD2,3:Mg2+ [plasma membrane]
Physical Entity
Activity
Orthologous Events
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