Reactome | NEU4 [lysosomal lumen]

NEU4 [lysosomal lumen]

Stable Identifier

R-HSA-1605806

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

Sialidase-4, NEUR4_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Sialic acid metabolism (Homo sapiens)
        
        NEU4 hydrolyses Neu5Ac from glycoconjugates (Homo sapiens)
        
        NEU4 [lysosomal lumen] (Homo sapiens)
        
        NEU4:GLB1:CTSA dimer [lysosomal lumen] (Homo sapiens)
        
        NEU4 [lysosomal lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WWR8 NEU4

Gene Names

NEU4, LP5125

Chain

chain:1-484

Reference Genes

BioGPS Gene:129807 NEU4

COSMIC (genes):NEU4 NEU4

CTD Gene:129807 NEU4

dbSNP Gene:129807 NEU4

ENSEMBL:ENSG00000204099 NEU4

ENSEMBL_homo_sapiens_GENE:ENSG00000204099.12 NEU4

ENSEMBL_homo_sapiens_GENE:ENSG00000277926.4 NEU4

HGNC:21328 NEU4

KEGG Gene (Homo sapiens):129807 NEU4

Monarch:129807 NEU4

NCBI Gene:129807 NEU4

OMIM:608527 NEU4

UCSC:Q8WWR8 NEU4

Reference Transcript

Other Identifiers

11730957_a_at

129807

222957_PM_at

222957_at

2536884

2536886

2536888

2536891

2536892

2536895

2536896

2536900

2536902

2536903

2536904

2536907

2536908

2536909

2536910

2536911

2536912

2536913

2536914

2536915

4046790

4046792

4046794

4046796

4046797

4046798

4046799

4046801

4046802

4046805

8049942

82995_at

A_24_P246891

GE484789

GE62151

GO:0003824

GO:0004308

GO:0005515

GO:0005737

GO:0005739

GO:0005741

GO:0005743

GO:0005764

GO:0005773

GO:0005783

GO:0005789

GO:0005886

GO:0005975

GO:0006516

GO:0006629

GO:0006689

GO:0008152

GO:0009313

GO:0010977

GO:0016020

GO:0016042

GO:0016787

GO:0016798

GO:0019866

GO:0030154

GO:0030163

GO:0031966

GO:0042995

GO:0043005

GO:0043202

GO:0043226

GO:0043231

GO:0048856

GO:0052794

GO:0052795

GO:0052796

GO:1901135

HMNXSV003052556

Hs.302024.0.S2_3p_at

Hs.302024.0.S2_3p_x_at

ILMN_2219683

PH_hs_0032576

TC02005018.hg

Participates

as a component of

NEU4:GLB1:CTSA dimer [lysosomal lumen] (Homo sapiens)

Inferred To

NEU4 [lysosomal lumen] (Bos taurus)

NEU4 [lysosomal lumen] (Canis familiaris)

NEU4 [lysosomal lumen] (Sus scrofa)

neu4 [lysosomal lumen] (Xenopus tropicalis)

Neu4 [lysosomal lumen] (Rattus norvegicus)

NEU4-2 [lysosomal lumen] (Gallus gallus)

NEU4-2 [lysosomal lumen] (Mus musculus)

Cross References

RefSeq

NP_001161071.1, NP_001161074.1, NP_001161073.1, NP_542779.2, NP_001161072.1

OpenTargets

ENSG00000204099

GeneCards

Q8WWR8

HPA

ENSG00000204099-NEU4

ZINC - Substances

NEUR4_HUMAN

ZINC target

Q8WWR8

Ensembl

ENSP00000375830, ENST00000618866, ENSP00000482722, ENST00000391969, ENST00000621851, ENSP00000478409, ENSP00000485701, ENST00000404257, ENSG00000277926, ENSP00000384804, ENSP00000486602, ENST00000616490, ENST00000325935, ENSP00000483726, ENSP00000320318, ENST00000630923, ENST00000407683, ENSG00000204099, ENST00000405370, ENST00000626600, ENSP00000385402, ENSP00000385149

PRO

Q8WWR8

Pharos - Targets

Q8WWR8

ZINC - Predictions - Purchasable

NEUR4_HUMAN