Reactome | GLB1 [lysosomal lumen]

GLB1 [lysosomal lumen]

Stable Identifier

R-HSA-1605623

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

Beta-galactosidase, BGAL_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P16278 GLB1

Gene Names

GLB1, ELNR1

Chain

signal peptide:1-23, propeptide:24-28, chain:29-677

Reference Genes

BioGPS Gene:2720 GLB1

COSMIC (genes):GLB1 GLB1

CTD Gene:2720 GLB1

dbSNP Gene:2720 GLB1

ENSEMBL:ENSG00000170266 GLB1

ENSEMBL_homo_sapiens_GENE:ENSG00000170266.16 GLB1

HGNC:4298 GLB1

KEGG Gene (Homo sapiens):2720 GLB1

Monarch:2720 GLB1

NCBI Gene:2720 GLB1

OMIM:611458 GLB1

UCSC:P16278 GLB1

Reference Transcript

Other Identifiers

11715657_a_at

11729661_a_at

11729662_x_at

201576_PM_s_at

201576_s_at

2668206

2668207

2668208

2668209

2668210

2668223

2668224

2668226

2668228

2668231

2668245

2668250

2668251

2668253

2668255

2668256

2668257

2668259

2668262

2668281

2668282

2668283

2720

37742_at

8086028

A_23_P61529

A_23_P61531

GE57941

GO:0003824

GO:0004553

GO:0004565

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005764

GO:0005773

GO:0005794

GO:0005975

GO:0006629

GO:0006790

GO:0008152

GO:0016787

GO:0016798

GO:0016936

GO:0019388

GO:0030163

GO:0030200

GO:0031410

GO:0035578

GO:0042340

GO:0042803

GO:0043202

GO:0043226

GO:0043231

GO:0046479

GO:0048471

GO:0051413

GO:0070062

GO:1901135

GO:1904016

GO:1904813

HMNXSV003034032

ILMN_1735155

ILMN_2289111

ILMN_2397721

M34423_at

PH_hs_0026028

g10834965_3p_a_at

Participates

as a component of

as a member of

BGAL [lysosomal lumen] (Homo sapiens)

Other forms of this molecule

GLB1 W509C [lysosomal lumen]

GLB1 Y83C [lysosomal lumen]

GLB1 R482C [lysosomal lumen]

GLB1 W273L [lysosomal lumen]

GLB1 [ficolin-1-rich granule lumen]

GLB1 [azurophil granule lumen]

GLB1 [extracellular region]

Inferred To

Glb1 [lysosomal lumen] (Rattus norvegicus)

bgal-1 [lysosomal lumen] (Caenorhabditis elegans)

Ect3 [lysosomal lumen] (Drosophila melanogaster)

Homologues of GLB1 [lysosomal lumen] (Caenorhabditis elegans)

Homologues of GLB1 [lysosomal lumen] (Drosophila melanogaster)

bgal-2 [lysosomal lumen] (Caenorhabditis elegans)

glb1l [lysosomal lumen] (Xenopus tropicalis)

Gal [lysosomal lumen] (Drosophila melanogaster)

glb1 [lysosomal lumen] (Dictyostelium discoideum)

GLB1 [lysosomal lumen] (Bos taurus)

GLB1 [lysosomal lumen] (Canis familiaris)

GLB1 [lysosomal lumen] (Gallus gallus)

GLB1 [lysosomal lumen] (Mus musculus)

GLB1 [lysosomal lumen] (Sus scrofa)

Cross References

RefSeq

NP_001129074.1, NP_001303969.1, NP_000395.2, NP_001073279.1

OpenTargets

ENSG00000170266

ZINC - Substances

BGAL_HUMAN

ZINC target

P16278

PRO

P16278

PDB

3THC, 3WF0, 3WF3, 3WF1, 3THD, 3WF4, 3WF2, 3WEZ

IntEnz

3.2.1.23

HPA

ENSG00000170266-GLB1

GeneCards

P16278

Ensembl

ENST00000307363, ENSP00000306920, ENSG00000170266, ENSP00000382333, ENST00000399402

Pharos - Targets

P16278

ZINC - Predictions - Purchasable

BGAL_HUMAN

Orphanet

16136

HMDB Protein

HMDBP00843

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.556	3
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.556	3
UniProt:P61586 RHOA	6	RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082) RHOA [cytosol] (R-HSA-194866) RHOA [cell junction] (R-HSA-2134503) RHOA [plasma membrane] (R-HSA-194510)	0.527	2
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.508	2

Cite Us!