Reactome | MMP7(51-267) [extracellular region]

MMP7(51-267) [extracellular region]

Stable Identifier

R-HSA-1604766

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

MMP7 intermediate form, Matrilysin-1, MMP7_HUMAN, MMP7

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P09237 MMP7

Gene Names

MMP7, MPSL1, PUMP1

Chain

signal peptide:1-17, propeptide:18-94, chain:95-267

Reference Genes

BioGPS Gene:4316 MMP7

COSMIC (genes):MMP7 MMP7

CTD Gene:4316 MMP7

dbSNP Gene:4316 MMP7

ENSEMBL:ENSG00000137673 MMP7

HGNC:7174 MMP7

KEGG Gene (Homo sapiens):4316 MMP7

Monarch:4316 MMP7

NCBI Gene:4316 MMP7

OMIM:178990 MMP7

UCSC:P09237 MMP7

Reference Transcript

RefSeq:NM_002423.4 MMP7

Other Identifiers

0001400605

11744030_a_at

11744031_at

11756074_a_at

16743647

204259_at

3388674

3388675

3388676

3388677

3388678

3388681

3388682

3388683

3388684

3388685

3388686

4316

668_s_at

7951217

A_23_P52761

GE60350

GO:0000003

GO:0003674

GO:0004175

GO:0004222

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0006508

GO:0006509

GO:0007568

GO:0008150

GO:0008201

GO:0008233

GO:0008237

GO:0008270

GO:0009056

GO:0009986

GO:0016787

GO:0022617

GO:0030198

GO:0030335

GO:0030574

GO:0031012

GO:0031293

GO:0031667

GO:0040011

GO:0043167

GO:0043226

GO:0044849

GO:0046872

GO:0048870

GO:0060135

GO:0070062

GO:0071260

HMNXSV003056491

ILMN_1685403

ILMN_2192072

L22524_s_at

PH_hs_0027041

TC11002228.hg

Participates

as an output of

Initial activation of proMMP7 by trypsin (Homo sapiens)

as an input of

Autocatalytic activation of MMP7 (Homo sapiens)

Other forms of this molecule

MMP7(18-94) [extracellular region]

MMP7(18-50) [extracellular region]

MMP7(18-267) [extracellular region]

MMP7(51-94) [extracellular region]

MMP7(95-267) [extracellular region]

Inferred To

mmp3 [extracellular region] (Xenopus tropicalis)

MMP7(51-267) [extracellular region] (Caenorhabditis elegans)

Mmp2 [extracellular region] (Drosophila melanogaster)

Mmp7 [extracellular region] (Mus musculus)

Mmp7 [extracellular region] (Rattus norvegicus)

zmp-6 [extracellular region] (Caenorhabditis elegans)

zmp-2 [extracellular region] (Caenorhabditis elegans)

zmp-5 [extracellular region] (Caenorhabditis elegans)

zmp-3 [extracellular region] (Caenorhabditis elegans)

zmp-4 [extracellular region] (Caenorhabditis elegans)

mmp30 [extracellular region] (Danio rerio)

MMP7 [extracellular region] (Bos taurus)

MMP7 [extracellular region] (Canis familiaris)

MMP7 [extracellular region] (Sus scrofa)

Mmp1 [extracellular region] (Drosophila melanogaster)

Homologues of MMP7(51-267) [extracellular region] (Caenorhabditis elegans)

Homologues of MMP7(51-267) [extracellular region] (Drosophila melanogaster)

Cross References

RefSeq

NP_002414.1

ZINC - World Drugs

MMP7_HUMAN

Guide to Pharmacology - Targets

1631

OpenTargets

ENSG00000137673

ZINC - Substances

MMP7_HUMAN

ZINC target

P09237

PRO

P09237

PDB

5UE2, 2Y6D, 1MMQ, 5UE5, 2DDY, 2MZH, 2MZI, 2Y6C, 2MZE, 1MMP, 1MMR

ZINC - Investigational

MMP7_HUMAN

GeneCards

P09237

HPA

ENSG00000137673-MMP7

Ensembl

ENST00000260227, ENSG00000137673, ENSP00000260227

Pharos - Targets

P09237

ZINC - Predictions - Purchasable

MMP7_HUMAN

HMDB Protein

HMDBP02928

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17931 LGALS3	3	LGALS3 [secretory granule membrane] (R-HSA-6803327) LGALS3 [plasma membrane] (R-HSA-879445) LGALS3 [ficolin-1-rich granule membrane] (R-HSA-6803307)	0.489	5

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