Autocatalytic activation of MMP7

Stable Identifier
R-HSA-1604763
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Once cleaved at Lys50-Asn51 MMP7 undergoes autocatalysis (Crabbe et al. 1992). Highly sulfated glycosaminoglycans (GAG), such as heparin, chondroitin-4,6-sulfate (CS-E), and dermatan sulfate, markedly enhance (>50-fold) the intermolecular autolytic activation of promatrilysin and the activity of fully active matrilysin (Ra et al. 2009).
Literature References
PubMed ID Title Journal Year
1390635 Biochemical characterization of matrilysin. Activation conforms to the stepwise mechanisms proposed for other matrix metalloproteinases

Docherty, AJ, Carne, AF, Eaton, D, Hynds, P, Crabbe, T, Willenbrock, F, Murphy, G

Biochemistry 1992
Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of MMP7(51-267) [extracellular region]

This event is regulated
Orthologous Events
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