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KLK2 [extracellular region]
Stable Identifier
R-HSA-1604753
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Kallikrein-2, Tissue kallikrein, KLK2_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Activation of Matrix Metalloproteinases (Homo sapiens)
Activation of proMMP8 (Homo sapiens)
proMMP8 initial activators [extracellular region] (Homo sapiens)
KLK2 [extracellular region] (Homo sapiens)
Activation of proMMP9 by proteases (Homo sapiens)
proMMP9 activating proteases [extracellular region] (Homo sapiens)
KLK2 [extracellular region] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
Prostate Specific Antigen [extracellular region] (Homo sapiens)
KLK2 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate PKNs (Homo sapiens)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Homo sapiens)
PKN1 in complex with AR positively regulates expression of KLK2 and KLK3 (Homo sapiens)
KLK2,KLK3 [extracellular region] (Homo sapiens)
KLK2 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20151 KLK2
Gene Names
KLK2
Chain
signal peptide:1-18, propeptide:19-24, chain:25-261
Reference Genes
BioGPS Gene:3817 KLK2
COSMIC (genes):KLK2 KLK2
CTD Gene:3817 KLK2
dbSNP Gene:3817 KLK2
ENSEMBL:ENSG00000167751 KLK2
HGNC:6363 KLK2
KEGG:hsa:3817 KLK2
Monarch:3817 KLK2
NCBI Gene:3817 KLK2
OMIM:147960 KLK2
UCSC:P20151 KLK2
Reference Transcript
RefSeq:NM_001002231.2 KLK2
RefSeq:NM_001256080.1 KLK2
RefSeq:NM_005551.4 KLK2
Other Identifiers
11729586_a_at
11729587_x_at
11729588_at
11729589_a_at
11729590_s_at
11729591_x_at
11750338_a_at
11751771_a_at
11751772_x_at
11760620_a_at
11760621_x_at
11763753_x_at
1555545_at
16864628
209854_PM_s_at
209854_s_at
209855_PM_s_at
209855_s_at
210339_PM_s_at
210339_s_at
217_at
3817
3839553
3839562
3839564
3839565
3839566
3839567
3839568
3839569
3839570
3839571
3839572
3839573
3839574
3839575
3839576
3839577
3839578
3839579
3839580
3839581
3839582
3839583
3839584
3839585
3839586
3839587
3839588
3839589
41721_at
8030768
83531_at
A_14_P125183
A_14_P135487
A_23_P310257
A_24_P5750
GE61160
GO:0003824
GO:0004252
GO:0005576
GO:0006508
GO:0008236
GO:0016787
GO:0030141
GO:0031410
GO:0043226
GO:0070062
GO:0140096
HMNXSV003008726
HMNXSV003034380
HMNXSV003039630
Hs.181350.0.S1_3p_a_at
Hs2Affx.1.363.S1_3p_at
ILMN_2335583
ILMN_2371917
PH_hs_0032033
S39329_at
TC19000771.hg
g13528791_3p_a_at
g6425047_3p_a_at
Participates
as a candidate of
Prostate Specific Antigen [extracellular region] (Homo sapiens)
proMMP9 activating proteases [extracellular region] (Homo sapiens)
as a member of
proMMP8 initial activators [extracellular region] (Homo sapiens)
KLK2,KLK3 [extracellular region] (Homo sapiens)
Inferred To
ENSRNOG00000066972 [extracellular region]
(Rattus norvegicus)
Klk7 [extracellular region]
(Rattus norvegicus)
ENSRNOG00000067174 [extracellular region]
(Rattus norvegicus)
ENSRNOG00000069479 [extracellular region]
(Rattus norvegicus)
Homologues of KLK3 [extracellular region]
(Rattus norvegicus)
Klk1b27 [extracellular region]
(Mus musculus)
Klk1b8 [extracellular region]
(Mus musculus)
Klk9 [extracellular region]
(Rattus norvegicus)
Klk1b21 [extracellular region]
(Mus musculus)
ENSRNOG00000071144 [extracellular region]
(Rattus norvegicus)
Klk1b11 [extracellular region]
(Mus musculus)
KLK2 [extracellular region]
(Canis familiaris)
KLK2 [extracellular region]
(Mus musculus)
Klk1b26 [extracellular region]
(Mus musculus)
Klk12 [extracellular region]
(Rattus norvegicus)
Homologues of KLK2 [extracellular region]
(Canis familiaris)
Homologues of KLK2 [extracellular region]
(Mus musculus)
Klk1b9 [extracellular region]
(Mus musculus)
Klk6 [extracellular region]
(Rattus norvegicus)
Klk1b5 [extracellular region]
(Mus musculus)
Klk1c4 [extracellular region]
(Rattus norvegicus)
Ngfg [extracellular region]
(Rattus norvegicus)
Klk10 [extracellular region]
(Rattus norvegicus)
Klk1b24 [extracellular region]
(Mus musculus)
Klk1b22 [extracellular region]
(Mus musculus)
Klk1b1 [extracellular region]
(Mus musculus)
Klk1b16 [extracellular region]
(Mus musculus)
Klk1 [extracellular region]
(Mus musculus)
Klk1c6 [extracellular region]
(Rattus norvegicus)
KLK3 [extracellular region]
(Rattus norvegicus)
KLK1 [extracellular region]
(Bos taurus)
KLK1 [extracellular region]
(Canis familiaris)
KLK1 [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_005542.1
,
NP_001002231.1
,
NP_001243009.1
Guide to Pharmacology - Targets
2372
ENSEMBL
ENST00000358049
,
ENST00000325321
,
ENSP00000350748
,
ENSP00000313581
,
ENST00000391810
,
ENSP00000375686
,
ENST00000597439
,
ENSP00000471214
OpenTargets
ENSG00000167751
ZINC - Substances
KLK2_HUMAN
ZINC target
P20151
PRO
P20151
GlyGen
P20151
PDB
4NFF
,
4NFE
IntEnz
3.4.21.35
HPA
ENSG00000167751-KLK2
Pharos - Targets
P20151
HMDB Protein
HMDBP13673
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